H2020Индивидуална стипендия2015–2016

GLOID · Genetic and Lifestyle Origins of Inflammation in Depression

„Хоризонт 2020“ — Действия „Мария Склодовска-Кюри“

Период: 2015-05-01 → 2016-10-31
Финансиране от ЕС: 133 199 €
Участници: 2
Схема: MSCA-IF-EF-ST

Линиите свързват координатора с партньорите.

Накратко на български

Генетичните фактори, метаболизмът и начинът на живот се анализират, за да се установи връзката им с възпалителните процеси при депресията. Това помага да се разберат биологичните причини за заболяването, тъй като сегашните антидепресанти не винаги действат оптимално.

Този кратък обзор е генериран от изкуствен интелект

Кратко обяснение, генерирано от езиков модел по текста на CORDIS. Оригиналът е по-долу.

Резултати накратко

Genetic and Lifestyle Origins of Inflammation in Depression

Depression is a relatively common mental illness that poses substantial societal costs. 15% of people in high income countries and 11% of people in low to middle income countries experience depression during their lifetime and many experience multiple episodes. Depression impairs a person’s ability to function in their role, causing reduced social and economic productivity. By 2030, depression will be the second largest cause of disease burden globally after HIV/AIDS. Thus, depression represents an urgent public health issue. Since the cause of depression is not well understood and current serotonin-based antidepressants are suboptimal, research to identify the biological and behavioural factors that contribute to the onset and remission of depression is critical. The aim of this Marie Skłodowska-Curie European Fellowship project was to examine evidence for the possible inflammatory, metabolic and lifestyle origins of depression. At the conclusion of the project we identified that people’s overall metabolic health and their lifestyle may have substantial consequences for their ongoing mental health.

Текст от CORDIS, на английски · Данни: CORDIS, © Европейски съюз

Цел на проекта

Depression produces substantial societal costs. Its cause is unknown and treatments are suboptimal. Inflammation may be involved in depression. People with depression have elevated levels of inflammatory mediators in the blood, although it is unclear whether the source is genetic, environmental, or some interaction. A likely environmental source is unhealthy lifestyle behaviours. To progress the field, studies must more directly test the causal status of the inflammatory hypothesis of depression; specifically, whether inflammation-related genetic polymorphisms or whole polygenic risk scores interact with unhealthy lifestyle in depression and its remission. I will address these unanswered questions in a Marie Skłodowska-Curie European Fellowship with Professor Penninx’s research group at VU University Amsterdam; world-leaders in the investigation of psychobiological causes of depression. I will collaborate with experts in genetic epidemiology and the inflammatory hypothesis of depression and complete sophisticated statistical analysis of data from the longitudinal Netherlands Study of Depression and Anxiety (NESDA; PI Professor Penninx). It will result in at least four peer-reviewed research articles, related conference presentations, and opportunities to more broadly disseminate the findings. Undertaking this research along with formal training and mentoring will enhance my academic profile, scientific experience, and content expertise in the psychobiological causes of depression, to enable me to develop into an independent, leading researcher. The proposed research contributes to the EU priority of addressing “societal challenges” to improve lifelong health and wellbeing of all. Providing evidence for the contribution of genetics, inflammation and unhealthy lifestyle to depression will provide opportunities for identifying people at risk of depression, treating depression, and developing individual and public health prevention strategies.

Оригинален текст от CORDIS (на английски).

Участници

STICHTING AMSTERDAM UMC · AmsterdamКоординаторНидерландия
STICHTING VU · AmsterdamНидерландия