H2020Индивидуална стипендия2015–2017

MANGANOXI · The development of manganese-based alkene epoxidation, cis-dihydroxylation and alkane C-H oxidation catalysts

„Хоризонт 2020“ — Действия „Мария Склодовска-Кюри“

Период: 2015-09-01 → 2017-08-31
Финансиране от ЕС: 195 455 €
Участници: 1
Схема: MSCA-IF-EF-ST

Линиите свързват координатора с партньорите.

Накратко на български

Нови катализатори на основата на манган се разработват за по-екологично окисляване на въглеводороди, например превръщането на алкени в епоксиди чрез водороден пероксид. Това помага за създаването на по-щадящи околната среда процеси при производството на лекарства и химикали.

Този кратък обзор е генериран от изкуствен интелект

Кратко обяснение, генерирано от езиков модел по текста на CORDIS. Оригиналът е по-долу.

Резултати накратко

The development of manganese-based alkene epoxidation, cis-dihydroxylation and alkane C-H oxidation catalysts

Hydrocarbons are widely available from fossil fuel sources but have little utility in the synthesis of more complex molecular structures in either academic or industrial settings due to their limited chemical reactivity. As a result they are converted into higher value fine chemicals through an array of industrial processes that are undertaken on a huge scale worldwide. Amongst the many transformations that can be used, oxidative processes are highly desirable due to their ability to rapidly introduce significant reactivity and structural complexity in simple organic structures, but are underutilised, frequently due to their high environmental impact. In this project we sought to develop new catalytic methodology for the environmentally benign oxidation of hydrocarbon substrates using hydrogen peroxide as the oxidant. We were particularly interested in developing systems capable of generating epoxides from alkenes, substrates which are widely used in the bulk chemical, fine chemical, pharmaceutical and agrochemical industries, which therefore have significant importance in wider society. The overall objectives of the project were to (i) investigate whether the addition of Lewis acid additives to a catalytic system that is known to be active in oxidative catalysis, which we have previously worked on, would result in an increase in reactivity; (ii) to develop a range of new ligand architectures to coordinate metals in which we included triazole moieties generated through ‘click’ reactions; the rationale for including the ‘click’ triazoles being that that they provided a similar structural motif to the commonly used pyridine ligand in other oxidative systems, allowed for modular syntheses to be developed and ultimately might provide a means of attaching the catalyst to solid supports; (iii) in the final objective we envisioned the use of solid supports to develop routes to heterogenised versions of the catalytic systems developed in (ii) so that they could be applied in flow reactors.

Текст от CORDIS, на английски · Данни: CORDIS, © Европейски съюз

Цел на проекта

The catalytic oxidation of alkenes to give epoxides and syn-diols, as well as the hydroxylation of C-H bonds in alkanes using environmentally benign reagents and conditions remains an area of significant challenge in contemporary synthetic chemistry and highly effective catalytic systems remains elusive. In the “MANGANOXI’ project a novel and ecologically friendly approach towards the development and application of manganese-based catalytic systems is proposed. The project first focuses on the use of a known manganese complex (MnTMTACN) together with Lewis Acids and hydrogen peroxide as a stoichiometric oxidant, generated using a co-catalyst from dioxygen, in the epoxidation of alkenes. The project will then develop analogues of other ligand systems to integrate ‘click’ generated 1,2,3-triazoles as pyridine surrogates, which should result in modular ligand systems which can be readily tuned. In addition, in order to obtain easier isolation of products and enable catalyst recycling, the most effective ligand systems will be anchored onto selected support using ‘click’ chemistry. The use of the copper-catalysed [3+2] ‘click’ Huisgen cycloaddition of an alkyne and azide is indispensable, as it facilitates both the anchoring of the ligand on the support and the incorporation of the pyridine surrogate into the ligand architecture. The catalytic oxidation reactions using the immobilized metal-ligand complex will then be conducted in a flow reactor, which will result in enormous potential of application in industry, by virtue of estimated high reproducibility and unrestrained scale-up of reactions. The “MANGANOXI’ project will not only contribute to European excellence and competiveness, but also reflects the principles of Green Chemistry and Technology for Sustainable Development.

Оригинален текст от CORDIS (на английски).

Участници

QUEEN MARY UNIVERSITY OF LONDON · LONDONКоординаторОбединеното кралство