MCMQCT · Multi-functional Computational Microscopy for Quantitative Cell Tracking
„Хоризонт 2020“ — Действия „Мария Склодовска-Кюри“
- Период
- 2015-08-01 → 2018-07-31
- Финансиране от ЕС
- 263 385 €
- Участници
- 2
- Схема
- MSCA-IF-GF
Линиите свързват координатора с партньорите.
Накратко на български
Нови микроскопи и софтуерни инструменти се разработват за по-бързо и евтино проследяване на клетки в биомедицински изследвания. Това ще помогне за намаляване на разходите и нуждата от висококвалифициран персонал, което да ускори диагностиката на заболявания и научните открития.
Кратко обяснение, генерирано от езиков модел по текста на CORDIS. Оригиналът е по-долу.
Резултати накратко
Multi-functional Computational Microscopy for Quantitative Cell Tracking
The invention of the optical microscope in the 16th century has changed the human race’s perception of the world forever. The ability to observe the world at the micron (1/1000-th of a millimeter) level, opened a window to the exploration of fundamental phenomena in biology, physics, materials science and medicine as it became an indispensable tool with direct implications for many aspects of our lives and enabling new inventions and insights. For global health, microscopes are the standard go-to tool in clinics for diagnosis of many types of conditions and diseases, as well as for fundamental research and scientific recreation. A few decades ago, the digital age was introduced to microscopy, with the advent of the digital cameras and the connection of these sensors to computers. This enabled a surge in development of novel measurement techniques, creating a new renaissance for microscopy and enabling automation and real time, longitudinal tracking of events, as they unfold in the microscopic or even nano-scopic (millionth of a millimeter) world. While these exciting technological advances were the enablers of progress in many fields, the demand for high quality imaging data is ever increasing, influenced by our own perception of modern image quality. However, state of the art optical microscopes are expensive, require a skillful human resource to operate and maintain them, which might create bottlenecks in clinics and research centers, where this resource is shared by numerous laboratories, which ultimately slows down diagnosis and discovery. In this project, we are developing novel microscopes and computational tools to address the issues of throughput, cost and labor required for biomedical imaging, for a new generation of optical microscopes with the ultimate goal of making biomedical imaging more accessible to clinics, research and recreation.
Текст от CORDIS, на английски · Данни: CORDIS, © Европейски съюз
Цел на проекта
Quantitative assessment of cellular phenotypes can result from various processes such as genetic manipulation, gene silencing, drug application or environmental changes. In many biological processes evident development of phenotypes often requires a long-term study of the sample, which can capture events at high-resolution and high frame rates. The essential working tool for this kind of studies is the optical microscope, which is essentially limited by a small field of view of the sample in two-dimensional (2D) environment, unsuitable for the quantitative assessment of cells in a more natural environment, in which they develop and evolve within complex communities. For this task, I purpose a novel platform based on a holographic on-chip microscopy which represents a new generation of computational microscopes, by integrating transformative technologies, which will ultimately enable five-dimensional, photodamage optimized at diffraction limited resolution, quantitative cell tracking. We believe that these functionalities and the platform's cost effectiveness will enable next generation high-throughput scientific research on the influence of drugs, genome modification and environmental changes, developing new models for cell locomotion, such as viral plague growth assays performed in hospitals and clinics, detection of parasites and bacteria in food/water and for education purposes, including in developing countries.
Оригинален текст от CORDIS (на английски).
Участници
- BAR ILAN UNIVERSITY · Ramat GanКоординаторИзраел
- THE REGENTS OF THE UNIVERSITY OF CALIFORNIA · OaklandСъединени щати
Връзки
Данни: CORDIS, © Европейски съюз