H2020Индивидуална стипендия2015–2017

VascColl · Temporally controlled delivery of vascular therapeutics from a regenerative template for diabetic wound healing

„Хоризонт 2020“ — Действия „Мария Склодовска-Кюри“

Период: 2015-05-01 → 2017-04-30
Финансиране от ЕС: 187 866 €
Участници: 1
Схема: MSCA-IF-EF-RI

Линиите свързват координатора с партньорите.

Накратко на български

Колагенов биоматериал с протеини, освобождавани чрез ултразвук, се тества за насочване на процесите по заздравяване на диабетични рани. Това е важно, защото такива рани трудно зарастват и често водят до ампутация на крайника.

Този кратък обзор е генериран от изкуствен интелект

Кратко обяснение, генерирано от езиков модел по текста на CORDIS. Оригиналът е по-долу.

Резултати накратко

Temporally controlled delivery of vascular therapeutics from a regenerative template for diabetic wound healing

Diabetic patients can suffer from diabetic foot ulcer (DFU) wounds, which are complex wounds that may not heal. Devastatingly, even with treatment, this can ultimately result in amputation of the affected limb. One reason that these wounds are challenging to heal is that they do not step through the normal wound healing sequence. If a solution to effectively heal these wounds could be developed, it would dramatically increase the quality of life for patients affected by diabetic foot ulcers. During this Marie Curie fellowship, the goal was to design a tissue engineering solution to treat diabetic foot ulcers, which would help guide the body in healing itself. The device used consists of a porous collagen biomaterial for cells to attach to and grow new tissue. In addition, small particles of gel containing proteins that can direct wound healing, can be incorporated into the collagen; when ultrasound is applied, the proteins are released. By releasing the proteins at specific time-points, the goal is to instruct the cells to progress normally through the wound healing stages. The overall objectives were to develop the device and to test the idea that delivering proteins at precise time-points can be used to co-ordinate and improve wound healing.

Текст от CORDIS, на английски · Данни: CORDIS, © Европейски съюз

Цел на проекта

Having recently returned to the EU following Graduate (Massachusetts Institute of Technology) and Postdoctoral Training (Harvard University) in the USA, I hope to work as a MSCA Reintegration Fellow to tackle a devastating element of the escalating epidemic of diabetes. Specifically, the lack of synchronicity in diabetic wound-healing can lead to chronic diabetic foot ulcers (DFUs), with limb amputation being the devastating consequence in many cases. Thus, the scientific goal of this proposal is to integrate my tools for temporally-controlled drug delivery with the existing collagen-based scaffold developed in Prof. Fergal O’Brien’s group at the Royal College of Surgeons in Ireland (RCSI). The proposed novel scaffold will be used to deliver vascular bioagents to DFUs, with ultrasound used as a trigger to delay the delivery of a vascular maturation bioagent. The target is to improve healing by stimulating vascularisation. The additional positive effects the bioagents may have on macrophage polarisation will be explored during a planned secondment.The training objective of this grant is to attain the requisite scientific and complementary skills so that I am fully prepared to run a research lab and teach in a top academic institution. This will be achieved through the expert supervision and input of Prof. O’Brien – and during a planned secondment – and will be backed up by colleagues in the lab and RCSI’s staff training activities. In addition, by managing the project, I will further develop skills relating to project planning and reporting, financial management, dissemination, patent filing and commercialisation. I will also continue to avail of opportunities to teach and to recruit and supervise students on this project or related works. If successful, this grant will help me establish an independent research niche in active and emerging research fields, while equipping me with the requisite skillsets to successfully work as an independent faculty member.

Оригинален текст от CORDIS (на английски).

Участници

ROYAL COLLEGE OF SURGEONS IN IRELAND · DUBLIN 2КоординаторИрландия