H2020Индивидуална стипендия2015–2017

REALISM · Reducing Early Atrophy with Leucine during Immobilization of Skeletal Muscle

„Хоризонт 2020“ — Действия „Мария Склодовска-Кюри“

Период: 2015-05-01 → 2017-04-30
Финансиране от ЕС: 177 599 €
Участници: 1
Схема: MSCA-IF-EF-ST

Линиите свързват координатора с партньорите.

Накратко на български

Загубата на мускулна маса при физическа неактивност, например при носене на гипс или лежане в леглото, се изследва чрез действието на аминокиселината левцин. Това помага за предотвратяне на физическата слабост и подобряване на здравето при възрастните хора.

Този кратък обзор е генериран от изкуствен интелект

Кратко обяснение, генерирано от езиков модел по текста на CORDIS. Оригиналът е по-долу.

Резултати накратко

Reducing Early Atrophy with Leucine during Immobilization of Skeletal Muscle

Recovery from injury, illness, and/or disease is associated with periods of physical inactivity and skeletal muscle disuse (e.g. due to bed rest or cast-induced limb immobilization). The physical inactivity associated with periods of muscle disuse results in a loss of skeletal muscle mass, leading to negative health consequences including reductions in muscle strength, the onset of insulin resistance, a decline in basal metabolic rate, and the accumulation of bodyfat. These conditions are associated with pre-mature physical frailty, elevated health care costs, and an increased risk of mortality. Furthermore, muscle disuse forms a major health concern for the elderly who are already at an increased risk for sarcopenia, or the age-related loss of skeletal muscle mass and strength. In fact, episodic periods of muscle disuse that are common in the elderly (e.g. due to injury, illness, or disease) are now thought to represent periods of “catabolic crisis” that significantly accelerate the progression of sarcopenia. Currently, older adults (age 60 or >) make up the fastest growing age group, with projections that the elderly will represent ~21% of the global population by the year 2050. Although older adults are living longer, they are not living well. Population studies demonstrate that sarcopenia affects >20% of people age 60-70, and ~50% of people >75. Direct healthcare costs attributable to sarcopenia in the USA were ~$18.5 billion in the year 2000. Clearly, it is critical to identify strategies that can effectively offset the loss of muscle mass that occurs in response to muscle disuse in order to prevent an epidemic of frailty among the elderly. The overall objectives of REALISM are as follows: 1. Identify whether MPB is elevated during the early (72 hours) stages of immobilization-induced disuse. 2. Identify whether leucine supplementation during this period of immobilization-induced disuse represents an effective nutritional intervention to attenuate MPB rates and preserve muscle mass. 3. Examine the impact of leucine supplementation on muscle mass and strength during 7 days of immobilization. 3. Identify whether cumulative MPS is reduced during the early (72 hours) stages of immobilization-induced disuse in the elderly. 4. Identify whether leucine supplementation during this period of immobilization-induced disuse represents an effective nutritional intervention to attenuate decline in cumulative MPS rates and preserve muscle mass in the elderly. The results from REALISM will identify the mechanisms underlying disuse-induced muscle atrophy in response to immobilization and examine potential therapeutic strategies to offset the loss of muscle mass and strength in younger and older adults.

Текст от CORDIS, на английски · Данни: CORDIS, © Европейски съюз

Цел на проекта

Recovery from injury, illness, and/or disease is associated with skeletal muscle disuse. Muscle disuse leads to a loss of muscle mass, strength, and functional independence, and represents a “catabolic crisis” for the elderly who are already at a greater risk for low muscle mass and strength due to age-related sarcopenia. Muscle mass is determined by the balance between muscle protein synthesis (MPS) and muscle protein breakdown (MPB). When MPB exceeds MPS, the result is a negative net protein balance and muscle loss. Decreased MPS rates occur following the onset of immobilization-induced disuse, but there is no information on the response of MPB. mRNA and protein expression data indicate that the early stages of disuse (0-5 days) result in activation of the ubiquitin proteasome system, and presumably MPB suggesting that the initial stages of disuse represent a critical period to intervene with appropriate countermeasures to attenuate the loss of muscle mass and strength. Leucine is a key amino acid in the regulation of muscle protein metabolism that has been shown to inhibit MPB. The current proposal REALISM will 1) identify whether MPB is elevated during the early stages (72 hours) of immobilization-induced disuse, 2) determine whether leucine can reduce MPB and the loss of muscle mass during the early stages of immobilization, and 3) determine whether leucine can preserve muscle mass and strength in the elderly during more prolonged periods of immobilization. REALISM will identify the mechanisms underlying disuse atrophy in response to immobilization and examine potential therapeutic strategies to offset the loss of muscle mass and strength. The M3 laboratory of Dr. van Loon at Maastricht University (UM) offers the most ideal environment for me to conduct REALISM, and take a major step towards the achievement of my career goal of setting up my own research program and establishing myself as an independent scientist.

Оригинален текст от CORDIS (на английски).

Участници

UNIVERSITEIT MAASTRICHT · MaastrichtКоординаторНидерландия