H2020Индивидуална стипендия2015–2017

SorCSbalance · Role of the sorting receptor SorCS1 in controlling excitation/inhibition balance in neural circuits.

„Хоризонт 2020“ — Действия „Мария Склодовска-Кюри“

Период: 2015-05-01 → 2017-04-30
Финансиране от ЕС: 160 800 €
Участници: 1
Схема: MSCA-IF

Линиите свързват координатора с партньорите.

Накратко на български

Рецепторът SorCS1 се изследва за това дали регулира баланса между възбуждащите и инхибиращите сигнали в мозъка чрез контрол на повърхностните рецептори. Разбирането на този механизъм помага при изясняването на причините за разстройства като аутизъм, шизофрения и болест на Алцхаймер.

Този кратък обзор е генериран от изкуствен интелект

Кратко обяснение, генерирано от езиков модел по текста на CORDIS. Оригиналът е по-долу.

Резултати накратко

Role of the sorting receptor SorCS1 in controlling excitation/inhibition balance in neural circuits.

Controlling the precise balance between excitation and inhibition (E/I balance) is critical for information processing in the brain. A perturbed E/I balance has been implicated in the etiology of a wide range of neuropsychiatric disorders. The factors that dictate the balance between excitatory and inhibitory synaptic transmission are still poorly defined, but trans-synaptic interactions between adhesion molecules such as neurexins and neuroligins are thought to be important. We had strong experimental evidence supporting the idea that SorCS1 is a pivotal regulator of synaptic abundance of adhesion molecules, however it was still unclear whether SorCS1 can regulate neuronal function or not. Considering that SorCS1 has also been associated with a variety of neural disorders, including autism, schizophrenia, and Alzheimer’s disease, here I hypothesized that SorCS1 controls E/I balance in the brain by regulating the synaptic abundance of cell surface receptors.

Текст от CORDIS, на английски · Данни: CORDIS, © Европейски съюз

Цел на проекта

Controlling the precise balance between excitation and inhibition (E/I balance) is critical for information processing in the brain. A perturbed E/I balance has been implicated in the etiology of a wide range of neuropsychiatric disorders. The factors that dictate the balance between excitatory and inhibitory synaptic transmission are still poorly defined, but trans-synaptic interactions between adhesion molecules such as neurexins and neuroligins are thought to be important. The host laboratory recently identified the sorting receptor SorCS1 as a key regulator of the synaptic abundance of glutamate receptors and adhesion molecules, including neurexins and neuroligins. SorCS1 has been associated with a variety of neural disorders, including autism, schizophrenia, and Alzheimer’s disease. I hypothesize that SorCS1 controls E/I balance in the brain by regulating the synaptic abundance of cell surface receptors. I shall test this hypothesis via the following specific aims:Aim 1: To analyse whether SorCS1 regulates synaptic trafficking of adhesion molecules and neurotransmitter receptors under basal conditions and during synaptic activity.Aim 2: To define how SorCS1 affects excitatory and inhibitory synapse function in vitro and in vivo.Aim 3: To determine whether perturbed SorCS1 levels and disease-associated SorCS1 mutations affect E/I balance in neural circuits.

Оригинален текст от CORDIS (на английски).

Участници

VIB VZW · ZWIJNAARDE - GENTКоординаторБелгия