H2020Индивидуална стипендия2016–2018

eADAM · Ultra-small electrochemical aptasensors for specific dopamine real-time monitoring

„Хоризонт 2020“ — Действия „Мария Склодовска-Кюри“

Период: 2016-02-01 → 2018-01-31
Финансиране от ЕС: 200 195 €
Участници: 1
Схема: MSCA-IF-EF-ST

Линиите свързват координатора с партньорите.

Накратко на български

Електрохимични сензори се разработват за точно проследяване на нивата на допамин в реално време, без смущение от други молекули. Това помага за по-доброто разбиране и ранната диагностика на заболявания като болест на Паркинсон, Алцхаймер и шизофрения.

Този кратък обзор е генериран от изкуствен интелект

Кратко обяснение, генерирано от езиков модел по текста на CORDIS. Оригиналът е по-долу.

Резултати накратко

Ultra-small electrochemical aptasensors for specific dopamine real-time monitoring

Psychiatric and neurodegenerative diseases (ND) associated with malfunctions in the brain´s neurotransmitter metabolism put a burden on the society shoulders. Only the costs of dementia approach 1% of world's GDP (US $818 billion in 2015) from where approximately 40% are derived from non-medical services (e.g. social services, special accommodation or informal care). Even more shocking is that a large majority of people living with ND do not receive a formal diagnosis, meaning they do not have access to treatment, care and/or support. A large number of these disorders (e.g. Parkinson’s and Alzheimer’s diseases, schizophrenia, drug addiction, or psychosis) are correlated with abnormal fluctuations in the levels of dopamine (a small molecule neurotransmitter secreted by the neurons in the brain). Therefore, it is not surprising that dopamine occupies a central piece in the current neuroscience research, aiming to understand the mechanism of the disease development and early diagnosis. The intrinsic electroactive nature of dopamine makes electrochemical methods very well suited for its monitoring. However, other co-existing molecules, such as nor/epinephrine, L-DOPA, catechol or ascorbic acid, provide signals in the range of potentials where dopamine is oxidized, thereby questioning the chemical selectivity of the measurements. The overall objective of this project was to develop electrochemical tools that ensure the specific measure of dopamine by this contributing to redefine the way dopaminergic diseases are monitored and treated.

Текст от CORDIS, на английски · Данни: CORDIS, © Европейски съюз

Цел на проекта

Nowadays, over 1.2 million people in Europe live with Parkinson’s disease (PD) considered as a complex disorder of unknown etiology, where an important number of cases are sporadic. In practice, the neurodegeneration associated with PD, also at the level of neurotransmitters (NT) misbalance, starts several years prior to the appearance of the cardinal symptoms. There are important evidences supporting that some environmental factors increase the risk of developing PD. Thus, there is the need of understanding their role and action mechanisms in order to develop therapeutic strategies and, even more important to minimize risks of PD development.The main aim of this project is to develop an ultra-small electroanalytical diagnostic platform for highly-specific real-time monitoring of NT, such as dopamine (DA). Several methods have been developed in order to address this issue, but in general they lack either specificity or high spatial/temporal resolution. In this project we propose to exploit the ability of nucleic acid aptamers to sensitively and selectively bind/catalytically transform DA and develop an ultra-small array platform for DA monitoring in small biological environments. The importance is that it will be used to measure nM/μs DA release from PC12 cells and drosophila flies, examine the molecular mechanisms of neuronal function/dysfunction, and further correlated them to particular PD risk factors.In a long-term perspective, the project aims microscopic sensors that may future be integrated with brain implants designed to restore local neuronal activity and/or NT release, such as deep brain stimulation electrodes, implanted to treat PD.

Оригинален текст от CORDIS (на английски).

Участници

AARHUS UNIVERSITET · Aarhus CКоординаторДания