H2020Индивидуална стипендия2015–2018

MolNANOtox · Nanomaterial surface interactions at the molecular level and their impact on ecotoxicity

„Хоризонт 2020“ — Действия „Мария Склодовска-Кюри“

Период: 2015-10-05 → 2018-03-18
Финансиране от ЕС: 195 455 €
Участници: 1
Схема: MSCA-IF-EF-ST

Линиите свързват координатора с партньорите.

Накратко на български

Наноматериалите и техният повърхностен слой, образуван от органични вещества и йони в природата, се анализират чрез специална спектроскопия. Разбирането на тези процеси помага да се оцени как частиците взаимодействат с живите организми и как влияят на околната среда.

Този кратък обзор е генериран от изкуствен интелект

Кратко обяснение, генерирано от езиков модел по текста на CORDIS. Оригиналът е по-долу.

Резултати накратко

Nanomaterial surface interactions at the molecular level and their impact on ecotoxicity

Nanotechnology has revolutionised many industries. Engineered nanomaterials (ENMs), the small, nanoscale materials at the heart of this technology, have novel and unique properties that drive the nanotechnology industry. However, increasing ENM abundance and availability has led to concerns regarding the risks they may pose to the environment. Significant advances have been made towards understanding ENM core chemistry, behaviour and transport, but a knowledge gap exists regarding their surface chemistry and its evolution in the environment, and how this may impact interactions with living organisms. In particular, the dynamic, environmentally-acquired surface coating called the “eco-corona” is a new concept that has seen little exploration until recently. The coating formed may be composed of entities right from small ions or molecules to large macromolecular material such as natural organic matter, and may have different attachment modes and strengths. Since ENMs have a high specific surface area and surfaces play a major role in ENM interactions and reactivity, understanding their surface chemistry is important in a comprehensive assessment of ENM fate and impact. The overall objective of the project was to characterise the fundamental interactions occurring at the surface of ENM and its impact on environmental ENM chemistry and bio-nano interactions with a range of analytical and imaging techniques. The project focused on the exploration of Raman spectroscopy and surface-enhanced Raman spectroscopy (SERS) as a novel application to probe the surface chemistry of ENMs in the context of eco-corona formation, as well as the application of a multimodal approach to imaging the bio-nano interactions.

Текст от CORDIS, на английски · Данни: CORDIS, © Европейски съюз

Цел на проекта

As nanotechnology continues to advance at an exponential rate, new products are continuously introduced into the market for research and consumer use. Engineered nanomaterials (ENMs), the functional components in these products, are often specifically designed to exploit the unique properties that nanomaterials exhibit; however, there is a widespread uncertainty on how these new properties may also potentially translate into novel risk issues in the environment. In particular, their high specific surface area and surface reactivity may promote distinct interactions with organisms particularly at the lower trophic levels. This can depend on both the intrinsic and extrinsic properties of ENMs, and can be affected by the formation of an “eco-corona”, which is composed of environmentally derived macromolecules from the milieu in which the ENMs are exposed that adsorb to the ENMs surface. However, understanding these interactions at the molecular level and their mechanistic consequences are severely limited and technically challenging, requiring a cross discipline approach. This project aims to address this knowledge gap by uncovering the underlying mechanisms for the formation and persistence of eco-coronas on a range of ENMs by combining fundamental ENM chemistry, environmental toxicology, advanced optical and mass spectroscopy and imaging techniques. In particular, this project will apply surface enhanced spectroscopic methods to characterise eco-corona composition and evolution and how this affects ENM interactions with, and impact upon unicellular organisms. By correlating the eco-corona composition with uptake route (or accumulation at external membrane) and toxicity response, and by investigating how these ENMs are partitioned within model species, the project proposes to identify the molecular basis that determines the fate and toxicology of ENMs in the environment.

Оригинален текст от CORDIS (на английски).

Участници

UNITED KINGDOM RESEARCH AND INNOVATION · SWINDONКоординаторОбединеното кралство