H2020Индивидуална стипендия2015–2017

ACT against AMR · Abyssomicin C Truncated derivatives against Antimicrobial Resistance

„Хоризонт 2020“ — Действия „Мария Склодовска-Кюри“

Период: 2015-05-01 → 2017-04-30
Финансиране от ЕС: 185 857 €
Участници: 1
Схема: MSCA-IF-EF-ST

Линиите свързват координатора с партньорите.

Накратко на български

Производни на веществото абисомицин C, извлечено от дълбоководни бактерии, се тестват като нови средства за борба с антибиотикорезистентните бактерии. Това е важно, защото т.нар. „супербактерии“ стават устойчиви на стандартните лекарства, което прави инфекциите по-трудни за лечение.

Този кратък обзор е генериран от изкуствен интелект

Кратко обяснение, генерирано от езиков модел по текста на CORDIS. Оригиналът е по-долу.

Резултати накратко

Abyssomicin C Truncated derivatives against Antimicrobial Resistance

Many recent human activities have strongly influenced our global environment, often in ways we have not been able to predict. An example is our use of antibiotics. The discovery of antimicrobials and their intense use, which started in the 1940s, had a deep impact on the human welfare, which over the last six decades has drastically improved. Their discovery has increased life expectancy considerably and has allowed the global health to reach higher standards. However, especially in the past decade, we have witnessed the exponential growth of antimicrobial resistant (AMR) bacteria, a threat that casts shadows over the medical “miracles” we take for granted. AMR bacteria, also known as “SuperBugs”, are normal pathogenic bacteria that have developed a resistance against commonly use antibiotics. This makes them resistant to treatments and potentially lethal. This project aims to offer a solid solution to the dwindling effectiveness of antibiotics against infectious diseases caused by the development of AMR bacteria. To achieve this goal we took as model abyssomicin C, which is a natural product isolated from an actinobacter found in deep-sea sediment of the Sea of Japan. Studies performed on this compound showed that it possess interesting antimicrobial activities in particular against AMR bacteria. The core of this proposal is to implement an innovative synthetic strategy to access truncated derivatives of abyssomicin C. The creation of a number of structurally related compounds together with computational studies will allow the identification of new potent antimicrobial agents, an important countermeasure against AMR bacteria. If successful, this project could have a deep impact not only in the scientific community but also on the healthcare systems in Europe and globally.

Текст от CORDIS, на английски · Данни: CORDIS, © Европейски съюз

Цел на проекта

This project aims to offer a solid solution to the dwindling effectiveness of antibiotics against infectious diseases caused by the development of antimicrobial resistant (AMR) bacteria. The core of this proposal is to implement an innovative synthesis-oriented strategy to access truncated derivatives of abyssomicin C, a natural product that has shown especially promising antimicrobial activity against the most common strains of antimicrobial resistant bacteria. The multiple routes proposed for the synthesis of the truncated core scaffold are short, robust and amenable for many different variations. This will open up for the possibility to easily synthesise a library of differently adorned abyssomicin C truncated analogues whose antimicrobial activity will be evaluated. Structure activity relationship (SAR) studies aided by computational modeling will be used as an integrated action in the identification of new potent antimicrobial agents.The complementary expertise of the applicant, the host laboratories and the leading experts that will collaborate within this project will be crucial for the realization of all aspects of this multifaceted project. The achievement of the project goals will have a deep impact not only in the scientific community but also on the healthcare systems in Europe and globally. This EF postdoctoral training proposal will represent a unique opportunity to the candidate to expand his scientific network in both the academia and the industry, greatly broaden his spheres of action, strengthening his professional maturity.

Оригинален текст от CORDIS (на английски).

Участници

GOETEBORGS UNIVERSITET · GoeteborgКоординаторШвеция