H2020Индивидуална стипендия2015–2017

GABACODEV · Role of GABAergic microcircuits with different embryonic origins in the orchestration of early cortical dynamics in the awake mouse pup

„Хоризонт 2020“ — Действия „Мария Склодовска-Кюри“

Период: 2015-04-01 → 2017-04-30
Финансиране от ЕС: 173 076 €
Участници: 1
Схема: MSCA-IF-EF-ST

Линиите свързват координатора с партньорите.

Накратко на български

GABA-ергичните микрокръгове в мозъка на мишета се изследват, за да се разбере как тези клетки координират развитието на невронните мрежи. Това помага да се разберат механизмите при разстройства като епилепсия, шизофрения и аутизъм.

Този кратък обзор е генериран от изкуствен интелект

Кратко обяснение, генерирано от езиков модел по текста на CORDIS. Оригиналът е по-долу.

Резултати накратко

Role of GABAergic microcircuits with different embryonic origins in the orchestration of early cortical dynamics in the awake mouse pup

One way to understand the complexity of neural circuits in the normal and pathological brain is studying their emergence during development. Connectivity between neurons arises during a developmental period characterized by the onset of spontaneous coordinated activity between large numbers of maturing neurons. Such synchronous activity is thought to strengthen/fine-tune connections between cells and leading to the formation of functional networks, that will provide the necessary framework to process external information. Evidence suggests that synchronous activity is a crucial phenomenon supporting cognitive processes. On the pathological side both an increase and a decrease in neural synchrony appears to be associated to disorders with a strong neurodevelopmental component, namely epilepsy, schizophrenia and autism. Although a large number of studies have addressed the role of synchrony in adult cognitive processes, little attention has been given to the synchronous network mechanisms underlying neural circuit maturation in the normal and pathological brain. Recent progress has demonstrated that interneurons (GABAergic cells) have an important active role in the onset of coordinated activity leading to the maturation of cortical neural networks. Hence the aim of the present proposal have focused on the role of GABAergic microcircuits in the maturation of cortical circuits in vivo, to understand how cortical interneurons integrate and functionally contribute to neural networks maturation during development.

Текст от CORDIS, на английски · Данни: CORDIS, © Европейски съюз

Цел на проекта

Because of its function in brain wiring and in the generation of early correlated activity patterns, the maturation of GABAergic transmission plays a key role in enabling brain complexity in higher mammals. Indeed, disruption of GABAergic circuitry at several time points can contribute to the generation of developmental disorders such as schizophrenia, autism or epilepsy (Le Maguerise and Moyner, 2013). Both in the murine hippocampus and neocortex, GABAergic interneurons have been shown to participate in the emergence of a precise temporal sequence of distinct correlated neuronal activity patterns during early postnatal development (Crepel et al., 2007; Allene et al., 2008). In particular, GABAergic cells with an extended and divergent axonal connectivity (operational “hub” neurons) (Bonifazi et al., 2009; Picardo et al., 2011; Cossart, 2013) have been described to be capable of synchronizing single-handedly populations of cells in developing hippocampal slices (Bonifazi et al., 2009). This project builds up on a solid ground of unpublished in vitro data from the host lab indicating that a specific, but diverse functional subpopulation of GABA neurons could also operate as hub cells in the developing neocortex. Experimentally, it will benefit from recent technical developments from the host lab aiming at manipulating and visualizing the activity of single neurons in the awake mouse combining genetic and microscopy tools. Indeed, if operational hub neurons have been described in vitro, it remains unknown how they integrate into functional networks in vivo, and more generally how GABAergic activity shapes early cortical network dynamicsThis proposal aims at translating from the in vitro to the in vivo situation a multidisciplinary approach to investigate the functional contribution of specific microcircuits to the emergence of network dynamics during development.

Оригинален текст от CORDIS (на английски).

Участници

INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE · ParisКоординаторФранция