H2020Индивидуална стипендия2015–2017

EPIGENHEART · Epigenetic control of retinoic acid-dependent genes during heart development

„Хоризонт 2020“ — Действия „Мария Склодовска-Кюри“

Период: 2015-07-01 → 2017-06-30
Финансиране от ЕС: 173 076 €
Участници: 1
Схема: MSCA-IF

Линиите свързват координатора с партньорите.

Накратко на български

Генните механизми, които контролират развитието на различни видове сърдечен мускул при ембрионите, се анализират чрез опити с мишки. Разбирането на тези процеси помага за изясняването на причините за вродените сърдечни дефекти, които са водеща причина за смъртност в света.

Този кратък обзор е генериран от изкуствен интелект

Кратко обяснение, генерирано от езиков модел по текста на CORDIS. Оригиналът е по-долу.

Резултати накратко

Epigenetic control of retinoic acid-dependent genes during heart development

EPIGENHEART has proposed a unique and competitive program for heart development research centered on heart malformations, a leading cause of death worldwide. Defects in the pathways for the myocardial lineages can result in various congenital malformations. My main objective has been to identify the transcriptional regulatory events that underlie the localized formation of the different types of myocardium of the embryonic heart. With the use of in vitro and in vivo approaches in transgenic and deficient mouse embryos combined with transcriptomic and chromatin profiling, the interacting research lines of EPIGENHEART is fulfilling this goal. There is a very small number of lab working on cardiac development in France compared to other EU countries and US. EPIGENHEART has allowed me to develop a novel line of research with the use of concepts and combined modern methods that no group in France has approached so far for understanding heart disease. In addition to the impact on human health, the project has contributed to future career prospects, France’s scientific excellence and competitiveness on the international level. With this funding support not only for my salary but also for my training activities and expenses related to my research costs, I have been able to strengthen my scientific expertise, leadership and management skills allowing me to reach a competitive position at the National Institute of Health and Medical Research (INSERM). http://www.zaffranlab.com/cardiogenese_en.html http://umr910.timone.univ-mrs.fr/

Текст от CORDIS, на английски · Данни: CORDIS, © Европейски съюз

Цел на проекта

EPIGENHEART proposes a unique and competitive training for heart development research centred on congenital heart diseases (CHD), a leading cause of death in Europe . Defects in the pathways involved in myocardial lineages at the venous pole of the heart are found to be the origin of CHD and atrial arrhythmias. Epigenetic gene regulation has influence in maintenance of cellular identity, differentiation, and is deregulated in many diseases. The involvement of epigenetic dysregulation in CHD is poorly described, much of the mechanistic detail involved in triggering these events in the context of heart development remains unclear. RA signalling is preferentially active in the venous pole region of the embryonic heart. A deregulation of the retinoic acid (RA) has been implicated in venous pole defects in patients. How RA signalling takes part in the genetic and epigenetic network regulating the venous pole lineage decisions needs to be studied in details. With the use of in vitro, ex vivo and in vivo approaches in transgenic and deficient mouse embryos combined with transcriptomic and chromatin profiling, the two interacting research lines of EPIGENHEART fulfils this goal. EPIGENHEART is expected to increase the knowledge on the genetic and epigenetic network regulating the formation of the venous pole, which will contribute to better understand the associated heart diseases. Apart from the impact on human health, the project will contribute to ER´s future career prospects and European scientific excellence and competitiveness.

Оригинален текст от CORDIS (на английски).

Участници

UNIVERSITE D'AIX MARSEILLE · MarseilleКоординаторФранция