germcells · A platform for the generation of human gametes in vitro
„Хоризонт 2020“ — Действия „Мария Склодовска-Кюри“
- Период
- 2016-03-01 → 2018-02-28
- Финансиране от ЕС
- 183 455 €
- Участници
- 1
- Схема
- MSCA-IF-EF-ST
Линиите свързват координатора с партньорите.
Накратко на български
Процесите по образуване на полови клетки при прасетата се анализират, за да се разбере как се развиват тези клетки в ембриона. Тези знания помагат за създаването на системи за производство на човешки гамети в лаборатория като алтернатива при лечение на безплодие.
Кратко обяснение, генерирано от езиков модел по текста на CORDIS. Оригиналът е по-долу.
Резултати накратко
A platform for the generation of human gametes in vitro
A key developmental event during embryogenesis is the differentiation of embryonic pluripotent cells into all the lineages that make an organism. A deeper understanding of how this processes are regulated will help in the design of novel procedures for the derivation of specific cell types in vitro. This project aims at gaining a better understanding of how the precursors of the gametes are formed in the embryo. Understanding how germ cells form in vivo is critical for developing culture systems to generate gametes in vitro as alternatives for treating infertility, a medical condition that affects up to 14% of couples in reproductive age. Among farm animals, the pig is recognised as an excellent model for studying multiple human diseases because of similar development and physiology to humans. In this project we use the pig to investigate early lineage decisions that lead to the formation of the gamete precursors. The overall objective of this project is to characterize the molecular program of pluripotency and the germ cell lineage in the pig by analysing the emergence of pluripotency during early embryo development, and characterizing germ cells specification in post-implantation embryos. This knowledge will allow the establishment of culture conditions for the derivation of pluripotent cells and gametes in vitro.
Текст от CORDIS, на английски · Данни: CORDIS, © Европейски съюз
Цел на проекта
According to the World Health Organization, infertility is a medical condition that affects up to 14% of couples under reproductive age. The increase in infertility has led to the exponential rise in the use of assisted reproduction as a route for conceiving a baby, currently representing 1.5% of children born in Europe. Although multiple factors may contribute to infertility, the limited availability of human gametes for its study restricts the capacity of researchers in establishing the causes of this decline. To address this limitation, a talented Fellow with background in physiology of reproduction will join a leading laboratory in developmental biology to conduct multidisciplinary research aimed at developing a platform for the generation of human gametes in the laboratory. A combination of state-of-the-art tools in genomics and cell biology will be used to gain new understanding of how gamete precursors form in vivo, and this knowledge will be used to develop culture systems to generate gametes in vitro. These approaches will equip the Fellow with comprehensive new skills essential for fulfilling these objectives. The transfer of knowledge builds on the host’s expertise in animal biotechnology, the provision of interdisciplinary training in human stem cell differentiation by collaborators, and on the Fellow’s knowledge of reproductive biology. The output of the project will address key societal challenges for the EU in the areas of Health, demographic change and well-being and will contribute to the expansion of the network of experts in biotechnology.
Оригинален текст от CORDIS (на английски).
Участници
- THE UNIVERSITY OF NOTTINGHAM · NottinghamКоординаторОбединеното кралство
Връзки
Данни: CORDIS, © Европейски съюз