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H2020Докторантска мрежа2015–2019

RENALTRACT · Development and disease of the renal tract

„Хоризонт 2020“ — Действия „Мария Склодовска-Кюри“

Период
2015-06-01 → 2019-05-31
Финансиране от ЕС
3 137 377 €
Участници
9
Схема
MSCA-ITN-ETN

Линиите свързват координатора с партньорите. За проекти отпреди 2014 г. CORDIS не винаги дава точни координати. Тези точки са на ниво град или държава.

Накратко на български

Генетичните и молекулярните механизми при формирането на отделителната система се изследват чрез модели като рибки и мишки. Разбирането на тези процеси помага при справянето с вродените дефекти на бъбреците, които често водят до тежки бъбречни заболявания при деца.

Този кратък обзор е генериран от изкуствен интелект

Кратко обяснение, генерирано от езиков модел по текста на CORDIS. Оригиналът е по-долу.

Резултати накратко

Development and disease of the renal tract

"The renal (urinary, excretory) tract plays a major role in the homeostasis of the body fluids. Thus, acquired or inherited defects in its anatomy and physiology have a severe impact on the quality of life. Renal tract malformations (RTMs) arise from perturbations of the embryonic programs that govern the formation and the assembly of the kidneys and the components of the lower urinary tract. RTMs occur in 3-6 per 1000 live births and cause 50-60% of end stage kidney disease (ESKD) in children and young adults. The current therapeutic options, surgery, renal dialysis and organ transplantation are of an enormous socio-economic impact that emphasizing the need to unravel the cellular and molecular mechanisms which guide the formation of this complex organ system from simple tissue rudiments. To make significant advances in understanding normal development and physiology of the renal tract, to unravel the nature of the disease-causing mechanisms of this organ system, and to establish therapeutic options, the RENALTRACT network aimed to structure its research around collaborative studies (1) to identify the genetic, epigenetic and regulatory networks guiding normal development and differentiation of the renal tract, using state-of-the-art non-human model systems (Drosophila, Xenopus, zebrafish and mouse); (2) to conduct high-throughput screening to molecularly dissect and understand the development of the renal tract; and (3) to discover and validate translational biomarkers by developing and studying different animal models. To make significant advances, RENALTRACT used a interdisciplinary approach combining experts and technologies of the physical sciences (imaging technology), chemistry (medicinal chemistry, metabolomics), biological sciences (developmental, cell biology, organ culture, physiology, genetics, “Omics”), systems biology and clinicians. To meet this challenge and train a new generation of researchers,12 ESRs were selected and deeply involved in a research programme targeting three scientific work packages (WPs): WP1 ""Genetic and epigenetic regulation of renal tract development""; WP2 ""Causes and mechanisms of renal tract malformation""; WP3 ""Renal tract research using high-efficiency in vivo models"". "

Текст от CORDIS, на английски · Данни: CORDIS, © Европейски съюз

Цел на проекта

The renal tract (kidneys, the ureters, bladder) is a complex organ system crucial for maintaining the body homeostasis. This organ system arises from different precursor pools through a complex program of patterning, differentiation and morphogenesis in embryonic development. Alteration of this program leads to renal tract malformations (RTM) that are incompatible with a healthy life. While some of these RTM can be surgically corrected, others develop into chronic entities that may lead to renal failure; the burden for the patients and for the socio-economic impact for the health systems is immense. Although congenital RTM are amongst the most frequent human birth defects, the different programs that direct normal and pathological development have remained poorly understood. The RENALTRACT training network aims to address these deficits and provide a better understanding of the programs that underlie RTM and provide solutions to clinical problems. This shall be achieved by using a multidisciplinary team approach with partners working in complementary disciplines (developmental biology, renal physiology, Omics, clinical medicine). RENALTRACT has unique and distinguishing features by uniting studies on components of the urinary tract, by building a bridge between basic and clinician scientists and by combining state of the art methods from a number of complementary fields in a variety of animal models.RENALTRACT aims to establish a first class multidisciplinary training program for outstanding Early-Stage Researchers (ESRs) to provide a group of young scientists with expert knowledge to envision and embark on novel therapies of renal tract malformations in the future. ESRs will benefit from an excellent working environment with state-of-the-art technologies and supervision by international leaders in the field and an inter-disciplinary approach. This will be complemented by intersectoral exposure and exchange between the RENALTRACT public and private participants.

Оригинален текст от CORDIS (на английски).

Участници

Връзки

Данни: CORDIS, © Европейски съюз