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КартаВръзкиТемиБългарияНощта (K-TRIO)Мария Склодовска-КюриЗа ученициЗа учителиМетодологияИзненадай ме
H2020Докторантска мрежа2015–2019

ENLIGHT-TEN · European Network linking informatics and genomics of helper T cells

„Хоризонт 2020“ — Действия „Мария Склодовска-Кюри“

Период
2015-10-01 → 2019-09-30
Финансиране от ЕС
3 354 685 €
Участници
18
Схема
MSCA-ITN

Линиите свързват координатора с партньорите.

Накратко на български

Т-хелперните клетки и техните генетични данни се анализират чрез информатика, за да се разбере как тези клетки се активират и развиват. Това помага за по-доброто контролиране на имунните реакции при лечение на автоимунни заболявания и рак.

Този кратък обзор е генериран от изкуствен интелект

Кратко обяснение, генерирано от езиков модел по текста на CORDIS. Оригиналът е по-долу.

Резултати накратко

European Network linking informatics and genomics of helper T cells

ENLIGHT-TEN was an ITN that provided cross-disciplinary training in T cell immunology and big data analysis and trained a new generation of researchers to exploit the power of emerging technological platforms to gain an in-depth knowledge of T cell differentiation and activation. This knowledge is critical to selectively manipulate T cell responses for therapeutic interventions in a wide-range of immune-mediated pathologies. The use of checkpoint inhibitors to increase anti-tumor responses has recently gained considerable attention, and suppressing T cell-mediated immune responses to ameliorate autoimmunity is an equally important goal. One of the challenges created by the rapid implementation of next-generation sequencing technologies is the gulf between laboratories having expertise in T cell biology and those being equipped to handle big data. Thus, ENLIGHT-TEN trained a cohort of early-stage researchers (ESRs) to be comfortable in both areas: to have an in-depth understanding of T cell biology alongside the capacity to generate and process large data sets. ENLIGHT-TEN has developed a cross-disciplinary, high-quality educational programme to provide all its ESRs with specialist high-level research training, a broad scientific skill set and experience in both academic and industrial working environments.

Текст от CORDIS, на английски · Данни: CORDIS, © Европейски съюз

Цел на проекта

ENLIGHT-TEN is a European Network Linking Informatics and Genomics of Helper T cells: our mission is to provide cross-disciplinary training in cellular immunology and big data analysis such that we train a new generation of researchers to fully exploit the power of emerging technological platforms. Our network of TEN beneficiaries combines T cell expertise with state-of-the-art technologies such as next generation sequencing (NGS), bioinformatics, multi-colour flow cytometry, preclinical models and tailored genome editing. Trainees will acquire a comprehensive knowledge in T cell immunology and the capacity to generate and interrogate big data sets as well as expertise in identifying novel biomarkers and developing therapeutic concepts. As such the training programme will provide an ideal stepping-stone for creative and innovative early stage researchers (ESRs) to enter and strengthen Europe’s academia as well as pharmaceutical and bioinformatics companies.The research focus of the network lies in the identification of extrinsic and intrinsic factors that control development, differentiation and plasticity of helper T cell subsets with particular emphasis on how T cell differentiation impacts on human diseases. The generation of large data sets is an emerging and challenging field, and there is high demand in both the academic sector as well as pharmaceutical companies for researchers to be able to analyse, integrate and exploit this rich source of information. ENLIGHT-TEN will combine the individual strengths of innovative laboratories and enterprises from complementary disciplines to provide unique interdisciplinary training for 13 ESRs, placing them at the forefront of this emerging field. Trainees will be empowered to perform cutting-edge analysis of the steadily increasing number of different T cell subsets, which play highly diverse and critical roles in the development of autoimmune diseases, making them a key target for pharmaceutical companies.

Оригинален текст от CORDIS (на английски).

Участници

Връзки

Данни: CORDIS, © Европейски съюз