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КартаВръзкиТемиБългарияНощта (K-TRIO)Мария Склодовска-КюриЗа ученициЗа учителиМетодологияИзненадай ме
H2020Докторантска мрежа2016–2019

BitMap · Brain injury and trauma monitoring using advanced photonics

„Хоризонт 2020“ — Действия „Мария Склодовска-Кюри“

Период
2016-01-01 → 2019-12-31
Финансиране от ЕС
3 835 764 €
Участници
13
Схема
MSCA-ITN-ETN

Линиите свързват координатора с партньорите.

Накратко на български

Биофотонни устройства измерват нивата на кислорода и метаболизма в мозъка при новородени и пациенти с тежки травми. Тези данни помагат за по-доброто управление на лечението чрез проследяване на биохимичните промени в тъканите.

Този кратък обзор е генериран от изкуствен интелект

Кратко обяснение, генерирано от езиков модел по текста на CORDIS. Оригиналът е по-долу.

Резултати накратко

Brain injury and trauma monitoring using advanced photonics

We are developing, testing and aiming to utilise safe, non-invasive devices for neuro-intensive care that will provide clinicians with valuable information about brain health when managing (1) critical patients such as those who have suffered a severe traumatic brain injury (TBI) and (2) neonates with a brain injury incurred during pregnancy and/or during birth (neonatal encephalopathy – NE). The early management and avoidance of brain tissue hypoxia and metabolic disturbances are the most significant factors influencing the outcome of treatment of severe TBI and NE. This requires adequate resuscitation and management in the early phase but unfortunately, significant improvements in treatment have been hampered by lack of knowledge of the biochemical, cellular and molecular changes involved in the pathophysiology of brain injury. The project is motivated by the clinical evidence that optical based devices can lead to significantly improved healthcare and reduced socio-economic impact. Specifically, we are targeting biomarkers (BM) of tissue hypoxia, ischemia and oxygen metabolism and aim to develop, investigate and validate devices that will measure the clinically relevant hemodynamic parameters. The ultimate goal of this work is for the first time to provide a set of standardised measurable quantities against which patients can be evaluated using biophotonic devices. Our approach is to use advanced photonic techniques that have already been shown to non-invasively provide hemodynamic parameters, namely: (1) near-infrared spectroscopy (NIRS) (2) time-resolved near-infrared spectroscopy (TRS-NIRS) and (3) diffuse correlation spectroscopy (DCS). We have brought together the leading optical imaging groups in Europe, major clinical centres of excellence and SMEs to form a multi-disciplinary consortium of scientists, engineers and clinicians who will work to ensure that (a) we will train the future scientific leaders (b) technology development is driven by clinical need and together will (c) facilitate the development of these into a set of smart probes that can be used routinely at the bedside.

Текст от CORDIS, на английски · Данни: CORDIS, © Европейски съюз

Цел на проекта

Our vision is to develop a suite of standardised non-invasive devices that will provide essential information about brain health in neurocritical care and neuromonitoring, with a particular emphasis on 1. traumatic brain injury: the “silent epidemic of the third millennium” and 2. hypoxia in newborn children. Survivors present permanent neurological conditions that have a profound impact on the quality of life of individuals and their families, and hence a large socio-economic impact. The key factors influencing these conditions and their treatment are the avoidance of brain hypoxia and metabolic disturbances and this is driving the transfer of new neuromonitoring systems to the bedside where they are being shown to have a transformative effect on patient care.BitMap will develop non-invasive photonics-based monitoring techniques and data analysis methods to provide biomarkers that could guide patient management. A cohort of multi-disciplinary Early Stage Researchers (ESRs), embedded in leading laboratories across Europe, will work together on an programme designed to address the key technological and clinical challenges in neurocritical care. The ESRs will benefit from the diverse range of expertise in advanced photonics and clinical application which will substantially enhance their research competitiveness and employability, and will together form a critical mass of skilled people working together towards new technologies for improved neuroclinical care.The challenges involved are fundamentally multi-disciplinary and therefore ESRs trained in a multi-disciplinary environment are essential if progress and clinical impact is to be made. There is currently no graduate programme producing researchers with these attributes, but there is a significant market for such PhDs in the rapidly developing area of biomedical optics and in general in medical imaging technology development. The BitMap project therefore addresses both a clinical and economicneed.

Оригинален текст от CORDIS (на английски).

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Данни: CORDIS, © Европейски съюз