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КартаВръзкиТемиБългарияНощта (K-TRIO)Мария Склодовска-КюриЗа ученициЗа учителиМетодологияИзненадай ме
H2020Докторантска мрежа2015–2019

TRAIN-ERS · Endoplasmic Reticulum Stress in Health and Disease

„Хоризонт 2020“ — Действия „Мария Склодовска-Кюри“

Период
2015-10-01 → 2019-09-30
Финансиране от ЕС
3 628 757 €
Участници
18
Схема
MSCA-ITN

Линиите свързват координатора с партньорите.

Накратко на български

Ендоплазматичният ретикулум обработва протеини, но при стрес те се нагъват неправилно, което може да доведе до рак или неврологични заболявания. Разбирането на този процес помага за разработването на нови терапии и методи за диагностика на тези болести.

Този кратък обзор е генериран от изкуствен интелект

Кратко обяснение, генерирано от езиков модел по текста на CORDIS. Оригиналът е по-долу.

Резултати накратко

Endoplasmic Reticulum Stress in Health and Disease

The endoplasmic reticulum (ER) folds and processes transmembrane and secreted proteins. Environmental and genetic factors can disrupt ER function causing misfolded & unfolded proteins to accumulate in the ER lumen – known as ER stress. Cells respond to different stressors by activating response pathways. The response to ER stress is called the Unfolded Protein Response (UPR). It aims to minimise cell damage and promote survival. If the damage is too great it can trigger cell death. ER stress is a key factor in the development of many diseases including cancer, neurodegenerative disorders, metabolic syndromes and inflammatory diseases. The molecular and cellular response to ER stress represents a potential therapeutic intervention point for the development of new therapies and diagnostic/prognostic markers for many diseases. There is a gap in our understanding of the molecular complexity of the ER stress response, how it determines cell fate, connects with other cellular processes and pathways, its regulation and, how it is deregulated in disease. This, coupled with limited numbers of skilled scientists in this area is hindering efforts to exploit the ER stress response for therapeutic/diagnostic purposes. TRAINERS brought young researchers together with world-leading academics, clinicians and industry personnel to increase understanding of the ER stress response and apply this understanding for the treatment of ER stress-associated diseases. The main aim was to increase understanding of a fundamental biological process involved in the development of many common diseases and to apply this understanding to develop new therapies. This requires well trained researchers with a broad range of transferable skills. TRAINERS provided high level training for young researchers ensuring they gained multidisciplinary and intersectoral research and training opportunities. The project strengthened links between academic researchers and industry partners accelerating discoveries in new therapeutics and diagnostics. Public engagement activities contributed towards attracting students towards careers in biomedical science, assuring Europe’s continued capacity to innovate. Outputs (presentations & publications) are already having an impact on the reputation of Europe for innovative and excellent research. Overall the generation of well-trained ESRs, the research produced and improved links between academia and industry have contributed to strengthening European innovation capacity and providing skilled researchers.

Текст от CORDIS, на английски · Данни: CORDIS, © Европейски съюз

Цел на проекта

Endoplasmic reticulum (ER) stress is emerging as a common feature in the pathology of numerous diseases including cancer, neurodegenerative disorders, metabolic syndromes and inflammatory diseases. Thus ER stress represents a potential therapeutic intervention point to be exploited to develop novel therapies, diagnostic tools and markers for these diseases. However, exploitation is hampered by the shortage of scientists with interdisciplinary training that can navigate with ease between the academic, industrial and clinical sectors, and that have the scientific and complementary skills, together with an innovative outlook, to convert research findings into commercial and clinical applications. This proposal will bring young researchers together with world-leading academics, clinicians and industry personnel, who are united in (1) their goal of forming a network of excellence aimed at understanding the ER stress response mechanistically and quantitatively and (2) applying this understanding to identify and validate the most suitable intervention points in order to provide innovative knowledge-driven strategies for the treatment of ER stress-associated diseases. The TRAIN-ERS network will provide early stage researchers (ESRs) with high quality scientific and complementary skills training combined with international, intersectoral work experience. This will produce highly trained, innovative, creative and entrepreneurial ESRs with greatly enhanced career prospects, who will continue to advance the state of the art in the Biomedical field in their further careers, and will confidently navigate at the interface of academic, clinical and private sector research. The TRAIN-ERS research programme will provide the ESR’s with the knowledge and the cutting edge scientific and technical skills that will drive our understanding and exploitation of the ER stress response for therapeutic and diagnostic purposes.

Оригинален текст от CORDIS (на английски).

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Данни: CORDIS, © Европейски съюз