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КартаВръзкиТемиБългарияНощта (K-TRIO)Мария Склодовска-КюриЗа ученициЗа учителиМетодологияИзненадай ме
H2020Обмен на изследователи2016–2019

ERROR · A pEdiatRic dosimetRy personalized platfORm based on computational anthropomorphic phantoms

„Хоризонт 2020“ — Действия „Мария Склодовска-Кюри“

Период
2016-01-01 → 2019-12-31
Финансиране от ЕС
432 000 €
Участници
6
Схема
MSCA-RISE

Линиите свързват координатора с партньорите.

Накратко на български

Платформата ERROR разработва метод за изчисляване на дозата радиация върху конкретни органи при деца по време на диагностика и лечение. Това е важно, защото децата са по-чувствителни към ionizing radiation и се нуждаят от персонализиран подход според възрастта и теглото си.

Този кратък обзор е генериран от изкуствен интелект

Кратко обяснение, генерирано от езиков модел по текста на CORDIS. Оригиналът е по-долу.

Резултати накратко

A pEdiatRic dosimetRy personalized platfORm based on computational anthropomorphic phantoms

Patient-specific internal dosimetry is of great interest, especially in childhood and puberty where the relative risk from the exposure to ionizing radiation compared to that for adults is widely debated. Pediatric dosimetry has been extensively discussed over the last two decades, in terms of administered activity reduction while retaining acceptable image quality of standalone acquisitions (CT,SPECT,PET) or hybrid examinations (SPECT/CT, PET/CT, PET/MR). The radiation absorbed dose delivered to pediatric patients in diagnostic and therapeutic procedures is still a matter of concern. Monte Carlo simulations is the gold standard method for accurate dosimetry assessment. However, due to complexity and large computational time needed, they are not applied in clinical routine. Instead, for couple of decades, there have been dosimetry factors calculated through MC techniques and are still applied for the estimation of the absorbed dose. Modern medicine requires alternative and updated techniques to approach personalized dosimetry, considering patient's individual anatomical characteristics. The main goal of the ERROR is the creation of a framework, freely available to the scientific community for the dose assessment on specific organs of interest in pediatric diagnostic and therapeutic applications. A novel methodology is applied to calculate dose factors for a pre-defined children population, acquiring realistic simulations, in terms of physics modeling, human anatomy, activity distribution/irradiation, low statistical uncertainty. The dosimetry framework will provide the definition of absorbed dose per organ according to the age, gender, weight, administered activity, duration time and the examination. In collaboration with the 3 academic partners, there is a novel combination of several methodologies and tools for achieving personalized pediatric dosimetry. Machine learning techniques, GPU based MC simulations, detailed anthropomorphic models, image processing algorithms, clinical pediatric data and feedback from clinicians will be used to facilitate the dosimetry calculation for each pediatric patient, based on pre-calculated data.

Текст от CORDIS, на английски · Данни: CORDIS, © Европейски съюз

Цел на проекта

The main objective of ERROR is to develop a new software tool, which will offer to the clinician the possibility to assess alternative imaging and therapeutic protocols, in real time, in silico, in order to minimize patient dose, while maintaining image quality of therapeutic effect. This tool will be designed, implemented and evaluated with specific focus on pediatric patients, since this is a rather sensitive target group, where dose considerations are high and no standard protocols and solutions exist. The project will exploit the new generation of computational anthropomorphic phantoms, in combination with well validated Monte Carlo simulations and Machine Learning Tools. In this way, it is envisaged that advanced, yet mature technologies will be integrated, to provide a novel tool, which can lead to a final product.The ERROR project brings together a multidisciplinary consortium of specialists in different areas of medical physics, biomedical engineering, physicians and computer engineers, who will join forces in order to design, implement and clinically assess a novel software tools, which initial focus in the optimization of diagnostic and therapeutic protocols for pediatric exams. Two new SMEs will provide their expertise, as well as investigate the ways to exploit project outcome.A well planned exchange program among academic and industrial partners will facilitate knowledge sharing, maximize collaborative work and finally achievement of project objectives. The consortium, being aware of the scientific and social importance of pediatric clinical applications, has planned a series of dissemination and training activities, aiming at making project knowledge and outcomes available to the scientific community and society.

Оригинален текст от CORDIS (на английски).

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Данни: CORDIS, © Европейски съюз