H2020Индивидуална стипендия2016–2018

PAIR · Physical Activity, Inflammation and Respiratory health: an integrative analysis of biological, behavioural and environmental determinants

„Хоризонт 2020“ — Действия „Мария Склодовска-Кюри“

Период: 2016-03-01 → 2018-02-28
Финансиране от ЕС: 170 122 €
Участници: 1
Схема: MSCA-IF-EF-ST

Линиите свързват координатора с партньорите.

Накратко на български

Редовната физическа активност, като интензивните упражнения, се изследва във връзката ѝ с белодробната функция и възпалителните процеси в организма. Това помага да се разбере как движението подобрява дихателното здраве дори при пушачи или хора в замърсен въздух.

Този кратък обзор е генериран от изкуствен интелект

Кратко обяснение, генерирано от езиков модел по текста на CORDIS. Оригиналът е по-долу.

Резултати накратко

Physical Activity, Inflammation and Respiratory health: an integrative analysis of biological, behavioural and environmental determinants

Physical inactivity is the fourth leading risk factor for global mortality and is strongly linked to major non-communicable diseases. At the time the PAIR project was funded, the evidence linking physical activity to respiratory health, such as lung function and chronic obstructive pulmonary disease, was weak, possibly as only a limited number of high-quality studies existed. The few available seemed to suggest that systemic inflammation may be one mechanism by which regular physical activity can improve respiratory health. Additional high-quality large studies were needed to test this hypothesis. The PAIR (Physical Activity, Inflammation and Respiratory health: an integrative analysis of biological, behavioural and environmental determinants) project aimed to fill this gap by investigating the effects of regular physical activity on lung function in a large sample of adults participating in the European Community Respiratory Health Survey. Overall, PAIR aimed to strengthen the evidence of a causal association between physical activity and lung function, and investigate potential underlying biological mechanisms. The three main conclusions of PAIR are • European adults who engage in regular vigorous physical activity (enough to make them out of breath or sweaty) have higher lung function, and this is especially true among current smokers. • Long-term air pollution levels observed in Western Europe don't negate the benefits of physical activity on lung function, which supports the promotion of outdoor activities and active transport. However, as the benefits of physical activity were reduced in never-smokers living in areas with very high air pollution levels, efforts at controlling air pollution levels are justified. • C-reactive protein (a commonly used biomarker for systemic inflammation) does not appear to have a causal role in the association between regular physical activity and higher lung function. Future studies are required to better understand the mechanistic pathways.

Текст от CORDIS, на английски · Данни: CORDIS, © Европейски съюз

Цел на проекта

The link between physical activity with respiratory health and chronic obstructive pulmonary disease (COPD) remains weak and under-investigated. The limited existing research seems to suggest that systemic inflammation could lie in the causal pathway of this relationship, and that inflammatory-related conditions may modify this potential causal mechanism, although these hypotheses remain largely understudied. This project will investigate 1) the effect of physical activity on lung function decline and COPD incidence in European adults, as well as 2) the mediating role of systemic inflammation and 3) the influence of biological (BMI, co-existing chronic inflammatory diseases), behavioural (diet, smoking) and environmental (air pollution, greenness, ultraviolet radiation) factors on this relationship. Data from over 18,000 subjects from 3 large population-based adult cohorts (ECHRS, SAPALDIA and NFBC), for which data on lung function and physical activity were prospectively collected during at least two follow-ups approximately a decade apart, will be included. Lung function was measured by spirometry according to international standards. Physical activity frequency, duration and type was collected using self-reported (ECRHS and NFBC) or interviewer-administered (SAPALDIA) questionnaires. Systemic inflammation will be assessed using C-reactive protein and interleukin-6 levels in serum. Data on the inflammation-related factors of interest were collected by the cohorts or derived from previous/ongoing collaborations. Cross-sectional and longitudinal associations, and potential interactive effects, will be examined by centre/cohort and combined estimates will be derived.Given that lung function is an important determinant of health and that physical activity is one of a very few prevalent individually-modifiable risk factors, the results of the proposed research have the potential for wide-spread implications as well as public health and economic impacts.

Оригинален текст от CORDIS (на английски).

Участници

FUNDACION PRIVADA INSTITUTO DE SALUD GLOBAL BARCELONA · BarcelonaКоординаторИспания