H2020Докторантска мрежа2016–2020

DISSection · Doctoral Industrial School on Human Skin models for Staphylococcal infections

„Хоризонт 2020“ — Действия „Мария Склодовска-Кюри“

Период: 2016-11-01 → 2020-10-31
Финансиране от ЕС: 1 026 871 €
Участници: 2
Схема: MSCA-ITN-EID

Линиите свързват координатора с партньорите.

Накратко на български

Бактерията Staphylococcus aureus и нейните фактори на патогенност се изучават чрез 3D модели на човешка кожа. Това помага да се разбере как патогенът заобикаля имунната система, тъй като животните не са подходящ модел за разработване на ефективни ваксини.

Този кратък обзор е генериран от изкуствен интелект

Кратко обяснение, генерирано от езиков модел по текста на CORDIS. Оригиналът е по-долу.

Резултати накратко

Doctoral Industrial School on Human Skin models for Staphylococcal infections

Staphylococcus aureus is a leading pathogen in surgical site and skin infections which are associated with an enormous unmet medical need. There are no licensed vaccines on the market despite the significant efforts by public and private initiatives. Indeed, vaccines tested in clinical trials in the last two decades have failed to show efficacy. Lack of known correlates of protection and reliable animal models are main reasons behind these failures. Skin is not only a major target of S. aureus infections of different severity, which often recur, but also the entry site for systemic infection and bacterial dissemination to distant sites. Since human skin is remarkably different from mouse skin, and S. aureus expresses several human-specific virulence factors, three-dimensional organotypic human skin models would represent a valid alternative to animal infection models. However, at present such models have not been established yet for S. aureus vaccine research. The aim of this project is to study the role of staphylococcal virulence factors in the pathogenesis and immune evasion within the human skin. To this end, the project aims at characterizing how expression of virulence factors is affected by the interaction with the skin and conversely, how skin resident immune cells respond to the pathogen. DISSection is a multidisciplinary project where four PhD students contribute to the study of S. aureus infection of human skin from different angles.

Текст от CORDIS, на английски · Данни: CORDIS, © Европейски съюз

Цел на проекта

Staphylococcus aureus (S. aureus) is a major human pathogen and cutaneous infections are among the leading cause of emergency department visits. Unfortunately, S. aureus vaccine development is hindered by the lack of known correlates of protection. Three dimensional organotypic human skin models may represent a valid alternative to animal infection model.Indeed, S. aureus expresses several human-specific virulence factors. However, at the present such models have been rarely used in the S. aureus research field and, to our knowledge, never with immune-competent models. Therefore, a major aim of this proposal is to develop a human skin equivalent and integrate key immune components in the epithelial matrix. To accomplish this goal we will take advantage of cutting-edge technologies, such as induced pluripotent stem cells to generate macrophages and neutrophils. The model will be used and optimized to the following main objectives: better understanding of human-specific pathogenesis of S. aureus as well as protective mechanisms against the pathogen; development of the first immune-competent human skin models for vaccine research; determine the role of bacterial communities on skin infections; provide alternative methods to animal models. The proposed scientific program will be complemented with a number of training courses based on specific skills for which both the University of Utrecht and Novartis Vaccines are renowned. Complementary courses on dermatology, human skin infections, hydrogel scaffolds, mass spectrometry, and induced pluripotent stem technology, will be held by associate partners. At the end of the project the students will receive a PhD degree in the area of Infection and Immunity. We believe that this project is at the leading edge of science and technology and represents a good opportunity for students that are willing to grow both in basic science as well as innovative and applicative research.

Оригинален текст от CORDIS (на английски).

Участници

GLAXOSMITHKLINE VACCINES SRL · SIENAКоординаторИталия
UNIVERSITAIR MEDISCH CENTRUM UTRECHT · UtrechtНидерландия