NEUTRO-LILR · Leukocyte immunoglobulin-like receptors (LILRs) on neutrophils
„Хоризонт 2020“ — Действия „Мария Склодовска-Кюри“
- Период
- 2016-10-03 → 2018-10-02
- Финансиране от ЕС
- 165 599 €
- Участници
- 1
- Схема
- MSCA-IF
Линиите свързват координатора с партньорите.
Накратко на български
Рецепторите от фамилията LILR регулират работата на неутрофилите – белите кръвни клетки, които първи атакуват микробите. Разбирането на тези механизми помага за разработването на нови терапии при инфекции и възпалителни заболявания.
Кратко обяснение, генерирано от езиков модел по текста на CORDIS. Оригиналът е по-долу.
Резултати накратко
Leukocyte immunoglobulin-like receptors (LILRs) on neutrophils
The NEUTRO-LILR project is a Marie-Curie actions Individual Intra-European Fellowship (IEF) based at the Department of Medical Microbiology, University Medical Centre Utrecht, Utrecht, The Netherlands. Neutrophils provide the first line of immune defense against invading microbes, and have key roles in orchestrating inflammation. Balanced neutrophils responses are critical to providing immunity and to prevent host tissue damage. A better understanding of the mechanisms that modulate neutrophils is required to identify the best strategies for modulation their activity and functions in disease situations. The project explored the role of the leukocyte immunoglobulin-like receptor (LILR) family in regulating neutrophils. Improved understanding of the role of LILRs as modulators of neutrophil functions, and the identification of novel LILR ligands, is vital to recognizing mechanisms and identifying tools that can be exploited in future immunotherapeutic strategies. This is important for identify the ebst strategies for immunomodulation of immune responses in infections or inflammatory disease situations. Our research demonstartes that LILRs modulate both activation and effector functions of neutrophils, and we have identified new LILR agonists and antagonists that may serve as the basis of new LILR targeting therapeutics.
Текст от CORDIS, на английски · Данни: CORDIS, © Европейски съюз
Цел на проекта
Neutrophils provide the first-line of antimicrobial defence and orchestrate inflammation. They are tightly regulated by ligand-receptor interactions to ensure pathogen clearance and to prevent host damage. Targeting receptors, with natural or synthetic ligands, that control neutrophil functions is a promising strategy to control infections and inflammation. However, basic knowledge on the role of certain receptors in neutrophil biology, and their interactions with pathogens, has been neglected. This includes leukocyte immunoglobulin-like receptors (LILRs), a family of surface receptors that are potent regulators of immune cell activity and potential targets of immunotherapeutic strategies. The major aim of this project is to comprehensively understand how LILRs regulate neutrophil functions, to identify bacterial ligands of LILRs and to test whether each bacteria-derived LILR ligand has pro- or anti-inflammatory properties that could be exploited in future immunotherapeutic strategies. For the first time, we will extensively characterise the functional role of four representative LILRs in controlling neutrophil functions. We will screen our newly developed high-throughput bacteria secretome phage display libraries, representative of 20 pathogens and the entire human gut microbiome, for identifying bacterial molecules that bind to LILRs. Finally, we will determine whether each of the ligands acts as a LILR agonist or antagonist. These experiments build upon expertise and preliminary results of the applicant, and upon unique resources of the host. The proposed experiments will expand knowledge of the function of poorly studied LILRs on neutrophils. This will advance knowledge of neutrophils, immune responses and bacterial pathogenesis, paving the way for identifying new strategies for treatment of infection and inflammation.
Оригинален текст от CORDIS (на английски).
Участници
- UNIVERSITAIR MEDISCH CENTRUM UTRECHT · UtrechtКоординаторНидерландия
Връзки
Данни: CORDIS, © Европейски съюз