H2020Индивидуална стипендия2016–2018

IMAGINE · Widefield Raman imaging probe for intraoperative margin assessment of cancers

„Хоризонт 2020“ — Действия „Мария Склодовска-Кюри“

Период: 2016-04-01 → 2018-03-31
Финансиране от ЕС: 183 455 €
Участници: 1
Схема: MSCA-IF-EF-ST

Линиите свързват координатора с партньорите.

Накратко на български

Раманската спектроскопия се използва за създаване на инструмент, който да разпознава остатъчни ракови клетки в тъканите по време на операция. Този метод помага за по-точното определяне на границите на тумора, което намалява риска от рецидив и подобрява качеството на живот на пациентите.

Този кратък обзор е генериран от изкуствен интелект

Кратко обяснение, генерирано от езиков модел по текста на CORDIS. Оригиналът е по-долу.

Резултати накратко

Widefield Raman imaging probe for intraoperative margin assessment of cancers

"Positive cancerous margins after surgery lead to an increased risk of progression and reduced disease free survival. Obtaining clear margins of cancerous lesions can be very challenging during surgery. Early identification and adequate surgical intervention are critical measures to reducing the cancer-related mortality rates and cost burden on the society. The inability to visualize the margin infiltration of cancers, however, represents a significant challenge in many areas of oncology. Hence, there is an imperative need to develop new imaging tools to visualize the margins of invasive cancers. The high recurrence rate and ongoing invasive monitoring requirement are the key contributors to the economic burden of cancer. With early detection and surgical intervention, the relapse and follow-up procedures would be greatly reduced, which in turn would have massive impact in terms of public health cost savings. Improved diagnosis would facilitate earlier and more efficient onset of treatment, and therefore the recurrence and follow-up procedures would be reduced, which in turn drastically reduces public health costs. Equally important, prognosis and patient quality of life improves drastically Raman spectroscopy is a unique label-free optical technique based on inelastic light scattering that offers tissue ""optical biopsy"" at the molecular level. The objective of “Widefield Raman imaging probe for intraoperative margin assessment of cancers”, abbreviated “IMAGINE”, was to develop a platform that can be used for intraoperative cancer margin assessment. I aimed to use this type of widefield imaging to increase the targeting selectivity and enhance the diagnostic efficacy for identifying tumour cells. A key part of the objective was transfer of knowledge between The Experienced Researcher and the Stevens Group. "

Текст от CORDIS, на английски · Данни: CORDIS, © Европейски съюз

Цел на проекта

Positive cancerous margins after surgery lead to an increased risk of progression and reduced disease free survival. Obtaining clear margins of cancerous lesions can be very challenging during surgery. Raman spectroscopy is a unique label-free optical technique based on inelastic light scattering that offers tissue ""optical biopsy"" at the molecular level. IMAGINE is a multidisciplinary approach that aims to develop the first widefield near-infrared (NIR) Raman imaging probe for intraoperative margin assessment. A new ultra-high sensitive InGaAs focal plane array (FPA) camera integrated with a novel combination of band-pass filters will be integrated to selectively probe the biomolecular constituents of tissues in the high-wavenumber range (i.e., 2800-3600 cm-1) providing a new endogenous biomolecular contrast mechanism for visualisation of resection margins during cancer surgery. A prototype will be developed and applied ex vivo on excised tissues from colorectal cancer patients. Histopathology will serve as gold standard and the sensitivity, specificy, receiver operating characteristics (ROCs), tumour contrast, and potential clinical/surgical impact will be evaluated. The new optical bioimaging modality proposed here constitutes a simple non-invasive cost-effective and broadly applicable technique for margin assessment of cancers compatible with in vivo laparoscopic settings. This translationally driven project fosters multidisciplinary research involving bioengineering, optical engineering and clinical research and has the support of a strong international industrial secondment. IMAGINE will enhance the mobility and innovative potential of the applicant and open new avenues in cancer surgery, which will strengthen the scientific excellence in Europe and ultimately benefit the patients.""

Оригинален текст от CORDIS (на английски).

Участници

IMPERIAL COLLEGE OF SCIENCE TECHNOLOGY AND MEDICINE · LondonКоординаторОбединеното кралство