H2020Индивидуална стипендия2016–2018

SPIN-MA · Schizophrenia Psychological Interventions Network Meta-Analysis of randomized evidence

„Хоризонт 2020“ — Действия „Мария Склодовска-Кюри“

Период: 2016-10-01 → 2018-09-30
Финансиране от ЕС: 159 461 €
Участници: 1
Схема: MSCA-IF

Линиите свързват координатора с партньорите.

Накратко на български

Психологическите методи за лечение на шизофрения се сравняват чрез специален анализ, за да се определи кой от тях е най-ефективен. Това помага на лекарите и пациентите да избират най-подходящия подход за терапия въз основа на наличните данни.

Този кратък обзор е генериран от изкуствен интелект

Кратко обяснение, генерирано от езиков модел по текста на CORDIS. Оригиналът е по-долу.

Резултати накратко

Schizophrenia Psychological Interventions Network Meta-Analysis of randomized evidence

Schizophrenia is a debilitating disorder that has a huge burden on patients, relatives and society in terms of loss of quality of life, loss of productivity and stigmatization. Psychological interventions are currently regarded as necessary to be integrated in the care for schizophrenia. In such a context, it is important to ascertain the efficacy and tolerability of psychological treatments, in order to provide patients and clinicians with information on the best treatment options and relieve the burden connected with this illness. However all the available knowledge about psychological treatments for schizophrenia is limited to pairwise meta-analyses, which are able to compare only two treatments at a time and to pool results only when a comparison of two treatments was considered in existing studies. The comparative efficacy of psychological interventions all together has not been checked yet. As a result, it is still currently unclear which are the most efficacious, the most acceptable and the best tolerable psychological treatments for schizophrenia. The aim of this project is to overcome this gap in the current knowledge applying a methodology called network meta-analysis. This novel approach allows to provide information on the comparison of two treatments even when they were not directly studied in a trial, and to have therefore a more comprehensive picture on the efficacy of the various psychological treatments. This is a key information at different levels: for patients, to be aware of the different treatment options and their efficacy, and be therefore active in the decision making process; for clinicians, in order to inform the individual decision making process of the best treatment approach for the individual patient; for policy makers, for meaningful allocation of resources and offer of the best treatment options at a larger scale.

Текст от CORDIS, на английски · Данни: CORDIS, © Европейски съюз

Цел на проекта

Schizophrenia is a severe mental illness with a huge burden on society. Consideration for multi-disciplinary and psychological treatments is raising, but a comprehensive evidence base on their efficacy is lacking from the literature. Taking advantage of my background in psychology and mental health research, I will apply an innovative statistical methodology to compare all existing psychological interventions for schizophrenia, called network meta-analysis. I will produce research evidence on the comparative efficacy of treatments even where a direct comparison has never been made, providing practitioners and policy makers with valuable knowledge for making decisions according to an evidence based medicine approach. This addresses several EU programs’ aims. I will be hosted at the Department of Psychiatry and Psychotherapy of Klinikum rechts der Isar der Technischen Universität München, under the supervision of Professor Stefan Leucht, who has outstanding expertise both in the field of schizophrenia treatment and in the methodology of NMA. A partner organization for highly specialized data analysis will be involved, with a secondment at University of Bern Institute of Social and Preventive Medicine, where I will work with Professor Georgia Salanti learning how to analyse collected data. Throughout all the project a transfer of knowledge perspective will be used, producing outputs to be delivered to policy makers (including World Health Organization, with whom I have an established collaboration) and other organizations involved in guideline production, as well as available to the community of European citizens with public outreach activities (the database will be made publicly available on the project’s website). As a result, novel evidence will be produced on this challenging topic. I will gain new skills and I will substantially increase my experience in research project management, networking and teaching, preparing for an independent position in academia.

Оригинален текст от CORDIS (на английски).

Участници

KLINIKUM DER TECHNISCHEN UNIVERSITÄT MÜNCHEN (TUM KLINIKUM) · MuenchenКоординаторГермания