H2020Индивидуална стипендия2016–2018

GSAORI · Guide Stars Adaptive Optics for Retinal Imaging

„Хоризонт 2020“ — Действия „Мария Склодовска-Кюри“

Период: 2016-04-01 → 2018-03-31
Финансиране от ЕС: 166 157 €
Участници: 1
Схема: MSCA-IF

Линиите свързват координатора с партньорите.

Накратко на български

Адаптивната оптика, заимствана от астрономията, се прилага за изясняване на изображенията на ретината, за да се видят отделни клетки. Това помага за по-ранно откриване на очни болести и по-добър контрол върху терапиите при повече пациенти.

Този кратък обзор е генериран от изкуствен интелект

Кратко обяснение, генерирано от езиков модел по текста на CORDIS. Оригиналът е по-долу.

Резултати накратко

Guide Stars Adaptive Optics for Retinal Imaging

The Guide Stars Adaptive Optics for Retinal Imaging (GSAORI) project aims at developing new retinal imaging techniques in the field of ophthalmology. This will enable images with cellular resolution of the retina that are essential for an early detection of retinal diseases, development of new therapies and for an improved therapy control. The eye presents some imperfections which leads to a blurring of the images and prevents imaging on a cellular level. Adaptive optics, a technique known from astronomy, can correct for this blurring and sharp images of the retina can be obtained. Thus extremely small details such as individual cells can be observed in the living human retina non-invasively. Although adaptive optics has enabled outstanding progresses in ophthalmology, it has its limitations. Pupil motion, tear film thickness changes during the examination, the structure of the diseased retina and permanent eye motion can limit the performance of the system. Therefore satisfactory image quality can only be achieved in healthy volunteers or carefully selected patients, which currently prevents a widespread use of this technology. Moreover, only small part of the retina can be imaged with classical adaptive optics systems, due to the variation of the imperfections within the eye. The ability to image larger patches of the retina would greatly improve the clinical interest of this technique. The overall objective of the project is to overcome these difficulties by developing more robust and more efficient adaptive optics systems. This will enable reasonable image quality in the majority of patients, on a relatively large field of view and in a short time. The emergence of such tool would be a significant milestone towards making this technique a routine for eye examination and, thus, would greatly improve diagnosis capabilities and reduce serious consequences of diseases that are diagnosed too late.

Текст от CORDIS, на английски · Данни: CORDIS, © Европейски съюз

Цел на проекта

The Guide Stars Adaptive Optics for Retinal Imaging (GSAORI) project aims at developing new imaging techniques in the field of ophthalmology. As the eye presents time-variable aberrations, an Adaptive Optics (AO) loop greatly enhances quality and resolution of retinal imaging, enabling the examination of structures such as cone and rod photoreceptors and leukocytes in vivo in a non invasive way and at a microscopic scale.Although AO has enabled outstanding progresses in ophthalmology, it has its limitation. The pupil motion and tear film thickness changes during the examination can limit the performance of the AO system. Also, the distortions of the retinal structure influence the wave-front analysis. Finally motion artefacts can have a strong impact on the correction capacity of the AO system. Therefore satisfactory image quality can only be achieved in carefully selected patients, which currently prevents a widespread use of this technology.The overall objective of the project is to overcome these limitations by developing systems that are more robust to retinal distortions and local media opacities. This will enable acceptable image quality in the majority of patients. The emergence of versatile AO systems would be a significant milestone towards making this technique a routine for eye examination.To achieve this goal, we propose to use guide stars that are spread over different locations of the retina to minimize the influence of eye’s defects on the wave-front measurements. This technique is directly inspired from astronomical telescopes where several laser guide stars are used as references to provide efficient wave-front correction on a large field of view. Following the conception of a system with guide stars, new algorithms for wave-front sensing and control will be developed, providing a fully functional innovative AO system. To fulfil its objectives, the research project will be based on extensive system modelling, and on in-vivo eyes’ measurements.

Оригинален текст от CORDIS (на английски).

Участници

MEDIZINISCHE UNIVERSITAET WIEN · WienКоординаторАвстрия