H2020Индивидуална стипендия2016–2018

CKD AKI · Chronic kidney disease and acute kidney injury – evaluation of EU and global epidemiology

„Хоризонт 2020“ — Действия „Мария Склодовска-Кюри“

Период: 2016-09-01 → 2018-11-02
Финансиране от ЕС: 168 277 €
Участници: 1
Схема: MSCA-IF-EF-ST

Линиите свързват координатора с партньорите.

Накратко на български

Разпространението на хроничните заболявания и острото увреждане на бъбреците се анализират в глобален мащаб и в ЕС. Данните помагат за по-добра грижа за пациентите, намаляване на смъртността и ограничаване на разходите за диализа и трансплантации.

Този кратък обзор е генериран от изкуствен интелект

Кратко обяснение, генерирано от езиков модел по текста на CORDIS. Оригиналът е по-долу.

Резултати накратко

Chronic kidney disease and acute kidney injury – evaluation of EU and global epidemiology

Kidney diseases are widespread and increasing non-communicable diseases with high burden, but their epidemiology is still insufficiently evaluated. Kidney diseases are defined as chronic kidney disease (CKD) or acute kidney injury (AKI) depending on their duration. CKD is a set of chronic conditions of different etiology that affects about 10-15% of general adult population as shown in the high-quality screening programs performed in different world regions. CKD has a profound impact on public health due to premature mortality, renal and cardiovascular complications. Renal complications with development of end-stage kidney disease (ESKD) require costly therapy with dialysis or transplantation and pose substantial economic burden, with the worldwide number of such patients is estimated at more than 3 million (of them about 400,000 in EU-25), and annual growth rate of 8%. The rates of cardiovascular complications are elevated independently of other risk factors even from the early CKD stages. AKI is characterized by the rapid loss of kidney function, and occurs in different settings, with higher rates among hospitalized or critically ill patients. AKI incidence varies from 295 to more than 5,000 cases per million population per year depending to its severity defined whether dialysis treatment is required or not. According England guidelines, prevention and delivery of optimal care for AKI could save about 12,000 lives and £150 million each year, and similar projections could be expected for all countries in EU. Both CKD and AKI more frequently affect elderly people and patients with diabetes mellitus that make both conditions even more important in the face of general population aging and worldwide growth of diabetes prevalence. The healthcare services are unequally provided for men and women, and studying sex and gender disparities in kidney disease burden should be one of the integrative measures of equal access to health care. The overall objectives of the project were to develop bibliographic system for collection of published data on CKD and AKI, to model kidney disease epidemiologic estimates on the global, regional, and country levels (including detailed estimates for European region) involving an international collaboration with leading institutes in the filed of non-communicable disease epidemiology, and to present the results of the project to public health stakeholders. The project has achieved these objectives, and provided substantial impact on the knowledge about kidney disease.

Текст от CORDIS, на английски · Данни: CORDIS, © Европейски съюз

Цел на проекта

Chronic kidney disease (CKD) and acute kidney injury (AKI) are widespread in EU and worldwide, and put substantial burden due to disability, mortality, high cost of treatment, and risk for development of cardiovascular diseases (CVD). Both CKD and AKI are projected to grow due to many factors, including general population aging and increase in diabetes prevalence. Evaluating global and EU regional epidemiology of CKD and AKI is extremely important for understanding current trends and future challenges, and revealing differences of kidney disease in diverse populations. The current proposal is aimed to develop a single database and bibliographic web-based tool for collecting available evidence on CKD and AKI epidemiology worldwide; develop and apply bibliographic search strategy to obtain literature sources and extract multiple epidemiologic parameters for CKD, AKI, and their connection to CVD; produce advanced models for CKD and AKI estimates on the global, regional, and country levels; strengthen existing international collaboration in studying CKD and AKI epidemiology; disseminate results to scientific community, public health authorities, and general public; increase future competiveness and prepare ER for tenure-track position in academic institutions in the EU-member states.The proposal assumes inter-disciplinary approach and international cooperation, contains several innovative elements, intended to produce multiple new deliverables, strength EU-based research, provide substantial career development for the researcher. Major issues in the proposal are directly related to consequences of population aging and increasing the burden of chronic diseases, as well as interconnections between acute and chronic diseases. The results are expected to provide important information for public health planning in EU and worldwide for comparing morbidity, mortality, and provision of medical care.

Оригинален текст от CORDIS (на английски).

Участници

ISTITUTO DI RICERCHE FARMACOLOGICHE MARIO NEGRI · MILANOКоординаторИталия