H2020Индивидуална стипендия2016–2018

ADAPTIVE INVERSIONS · Chromosomes on shuffle: disentangling the relative contributions of natural selection, sexual selection, and drift on the evolution of a chromosomal inversion.

„Хоризонт 2020“ — Действия „Мария Склодовска-Кюри“

Период: 2016-05-01 → 2018-04-30
Финансиране от ЕС: 173 857 €
Участници: 1
Схема: MSCA-IF-EF-ST

Линиите свързват координатора с партньорите.

Накратко на български

Хромозомните инверсии – обърнати участъци от ДНК – се изучават при мухата Coelopa frigida, за да се разбере как се променят гените в тях. Това помага да се разбере как естественият и сексуалният подбор влияят върху еволюцията и адаптацията на видовете.

Този кратък обзор е генериран от изкуствен интелект

Кратко обяснение, генерирано от езиков модел по текста на CORDIS. Оригиналът е по-долу.

Резултати накратко

Chromosomes on shuffle: disentangling the relative contributions of natural selection, sexual selection, and drift on the evolution of a chromosomal inversion.

Evolution is defined as a change in allele frequency over time. However, most work in the field of evolutionary biology concentrates on single nucleotide polymorphisms (SNPs) while other types of mutations (large insertions/deletions, structural rearrangements) are largely ignored. Chromosomal rearrangements, such as inversions (a piece of chromosome that is flipped relative to its normal orientation), are large-scale structural mutations that may encompass millions of nucleotides. Inversions segregate together as a single unit due to repressed recombination. Once thought to be relatively rare, the genomic revolution has revealed that inversions are orders of magnitude more common than previously thought and occur in a wide variety of taxa. Moreover, inversions are often found to have facilitated evolutionary processes such as adaptation and speciation. Despite their frequency and importance, we still lack an understanding of how and why inversions evolve. The key objective of this project was to strengthen our understanding of inversion evolution by systematically examining and disentangling the forces that govern the evolution of an inversion in a model species, the seaweed fly Coelopa frigida. Coelopa frigida inhabits “wrackbeds” (accumulations of decomposing seaweed) and has a paracentric inversion polymorphism on chromosome I (spanning 10% of the genome and containing at least 100 genes) that consists of an α and β version. Specifically, this research aimed to determine how natural and sexual selection govern the evolution of both regulatory and coding variation in an inversion polymorphism in C. frigida.

Текст от CORDIS, на английски · Данни: CORDIS, © Европейски съюз

Цел на проекта

Comprehending adaptation is key to understanding our changing world. Despite this, we still know little about the genetic basis of adaptation. The picture becomes even more complex when we move beyond base pairs to large structural variation. Inversions may contain hundreds or thousands of loci but segregate largely as one unit, as they prevent recombination. Nonetheless, these giant genomic units seemingly facilitate rapid adaptation and speciation in a wide variety of taxa. The key objective of this project is to determine how inversions contribute to adaptation and how they evolve by systematically examining and disentangling the forces that govern the evolution of an inversion in a model species, the seaweed fly Coelopa frigida. I will combine interdisciplinary techniques to address crucial and novel aspects of the relationship between inversions and adaptation. I will be based at the Linnaeus Centre for Marine Evolutionary Biology (CeMEB), an interdisciplinary centre of research excellence at the University of Gothenburg (UGOT) in Sweden. Via training-through-research including a secondment to the Instituto Gulbenkian de Ciência in Portugal I will learn new techniques from multiple disciplines, including advanced scripting for analysis of next generation sequencing data, theoretical modelling, and reduced representation library preparation and analysis.

Оригинален текст от CORDIS (на английски).

Участници

GOETEBORGS UNIVERSITET · GoeteborgКоординаторШвеция