H2020Индивидуална стипендия2016–2018

DE-STRESS · Decoding Stress Resilience

„Хоризонт 2020“ — Действия „Мария Склодовска-Кюри“

Период: 2016-07-01 → 2018-06-30
Финансиране от ЕС: 187 866 €
Участници: 1
Схема: MSCA-IF-EF-ST

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Накратко на български

Биологичните механизми за устойчивост на стреса се изследват чрез модели, които разграничават податливите от устойчивите индивиди. Това помага за разработването на терапии, които не само лекуват депресията, но и укрепват защитата на организма срещу бъдещ стрес.

Този кратък обзор е генериран от изкуствен интелект

Кратко обяснение, генерирано от езиков модел по текста на CORDIS. Оригиналът е по-долу.

Резултати накратко

Decoding Stress Resilience

• What is the problem/issue being addressed? Stress-induced psychopathologies such as depression are the most prevalent mental health disorders worldwide and impose a significant burden on society. A conventional approach to developing therapeutic strategies in this context is to create preclinical models which incorporate acute or chronic stress exposure. Such paradigms enable the discovery of causative links between stress, its effects on the central nervous system and the onset of behaviours in the model which are clinically relevant. These links, in turn, form the basis for developing novel therapeutics. However, as evidenced by several recent reports, this drug discovery scheme has, to date, yielded only modestly efficacious antidepressants and a significant proportion of patients are treatment-resistant. Against this background, over the last two to three decades our perspective of stress as a risk factor with a predetermined detrimental outcome has shifted significantly to one where stress induces a spectrum of phenotypes and at opposing ends lie individuals who are stress-resilient and stress-susceptible. Accordingly, the experimental aims of the project undertaken was to use a preclinical paradigm to identify mediators of stress-resilience and study their functional roles. • Why is it important for society? From a therapeutic standpoint, identifying the central and peripheral processes which underlie the former could form the basis for therapeutic strategies which not only treat stress-induced psychopathologies but also build resilience against future stress exposure. • What are the overall objectives? The first objective of the project was to develop a preclinical paradigm which could be used to examine physiological, neurobiological and behavioural phenotypes of stress-susceptibility and stress-resilience. The second aim of the project was to use orthogonal techniques to identify central and peripheral mediators of stress resilience. The specific focus of the project was a brain region called the bed nucleus of the stria terminalis (BNST) and changes in gene expression within this structure. The third and final objective was to examine the functional roles of the identified mediators of resilience and susceptibility.

Текст от CORDIS, на английски · Данни: CORDIS, © Европейски съюз

Цел на проекта

Stress is a common feature of our lives yet some people respond to stress better than others, a concept known as resilience. There is a growing body of experimental data which has implicated several brain structures and molecular mechanisms. However to date there has been limited focus on the bed nucleus of the stria terminalis (BNST) and the mechanisms in this brain region which could be involved. One of several proteins expressed by the BNST, which is a key regulator of the stress response, is the pituitary adenylate cyclase-activating peptide (PACAP). But the expression of PACAP is under the control of stress-responsive nucleotides called miRNAs. Thus, there exists a complex system in the BNST which regulates the stress-response and hypothetically could be involved in mediating resilience. To test this hypothesis, the DE-STRESS project will conduct a series of experiments with the objectives of (i) determining whether PACAP expression in the BNST is different in states of resilience and susceptibility, (ii) identifying miRNAs that are differentially expressed in these states and which regulate PACAP expression and (iii) elucidating their functional effects on the stress response. Hence, the DE-STRESS project uses an innovative approach to decode the concept of stress resilience and will advance understanding of the pathophysiology of stress-induced disorders. Additional objectives of the project include dissemination and transfer of knowledge to relevant stakeholders, forming collaborations within academia and industry with a view to commercialising research findings as well as develop project management and career development skills of the applicant. In line with the Work Programme for the MSCA fellowships, the knowledge and competencies gained by the applicant will add to developing his potential to achieve professional maturity and leadership in the field so that he may continue to make significant contributions to society and the economy.

Оригинален текст от CORDIS (на английски).

Участници

UNIVERSITY COLLEGE CORK - NATIONAL UNIVERSITY OF IRELAND, CORK · CorkКоординаторИрландия