H2020Индивидуална стипендия2017–2019

CorCir · Cortical circuit assembly in the developing mouse neocortex

„Хоризонт 2020“ — Действия „Мария Склодовска-Кюри“

Период: 2017-08-15 → 2019-08-14
Финансиране от ЕС: 183 455 €
Участници: 1
Схема: MSCA-IF-EF-ST

Линиите свързват координатора с партньорите.

Накратко на български

Молекулярните механизми, които контролират оцеляването и смъртта на определени неврони в развиващия се мозък на мишки, са в центъра на анализа. Разбирането им помага да се разберат причините за разстройства като аутизъм, шизофрения и епилепсия.

Този кратък обзор е генериран от изкуствен интелект

Кратко обяснение, генерирано от езиков модел по текста на CORDIS. Оригиналът е по-долу.

Резултати накратко

Cortical circuit assembly in the developing mouse neocortex

Imbalance of the excitatory-inhibitory neurons is a hallmark of several neurodevelopmental disorders such as epilepsy, autism and schizophrenia. Despite being a common theme in these disorders, the establishment of this balance in the developing brain and how it may contribute to cortical circuit assembly remains unknown. Understanding the molecular mechanisms involved in the establishment of this excitatory-inhibitory balance is vital in (1) understanding the critical developmental time period in which this balance is established, (2) providing insights into the aetiology of neurodevelopmental disorders and (3) identifying potential therapeutic avenues that can prevent and/or correct this imbalance during development. Consequently, one of the main aims of the research project is to determine the molecular mechanisms that regulate inhibitory cell survival in the developing cortex. More specifically, the aim of this project is listed as follows (1) Characterisation of programmed cell death within the neuronal population in the developing mouse brain. (2) Establishment of the molecular mechanisms driving interneuron cell death during mice postnatal development.

Текст от CORDIS, на английски · Данни: CORDIS, © Европейски съюз

Цел на проекта

The developing neocortex consists of two major neuronal subtypes–pyramidal neurons and interneurons. These two subtypes come together in the cortical plate, forming cortical circuits that can integrate and respond to external and internal stimuli. Despite recent advancement in the research on cortical networks of the developing brain, the mechanism involved in cortical circuit assembly remains relatively unexplored. This project aims to identify the sequence of events and factors involved in cortical circuit assembly in the developing mouse brain. As such, this project can be broadly divided into three main parts namely lamination, synaptogenesis and maturation of the MGE interneurons specifically. Currently, the exact mechanisms that govern MGE interneurons are still unknown except that it may involve cues that are produced by the pyramidal neurons. Therefore, we aim to use existing transcriptome data of the different neuronal layers coupled with the acquisition of the early- and late- born MGE interneurons transcriptome in order to identify the receptor-ligand pair that is involved in the specific lamination of MGE interneuron. We also aim to understand the sequence of events that occur during synaptogenesis and maturation of MGE interneurons. To achieve this, we will be performing live imaging on organotypic brain slices of sparsely labeled MGE interneurons and by selectively killing specific classes of interneurons in order to determine the effect of these cells on the maturation of the parvalbumin-expressing interneuron. Altogether, this proposed project will give a better insights into the factors and mechanisms underlying cortical circuit assembly in the developing brain and will pave the way for a better understanding into the aetiology of certain neurodevelopmental disorders.

Оригинален текст от CORDIS (на английски).

Участници

KING'S COLLEGE LONDON · LondonКоординаторОбединеното кралство