H2020Индивидуална стипендия2016–2018

PepPtNPAntiCan · Peptide Coated Platinum Nanoparticles as Antitumor Agents

„Хоризонт 2020“ — Действия „Мария Склодовска-Кюри“

Период: 2016-03-01 → 2018-02-28
Финансиране от ЕС: 187 420 €
Участници: 1
Схема: MSCA-IF-EF-ST

Линиите свързват координатора с партньорите.

Накратко на български

Платинени наночастици, покрити с пептиди, се тестват като средство за по-точното унищожаване на ракови клетки. Това помага за намаляване на токсичността и преодоляване на резистентността към стандартните химиотерапевтични лекарства.

Този кратък обзор е генериран от изкуствен интелект

Кратко обяснение, генерирано от езиков модел по текста на CORDIS. Оригиналът е по-долу.

Резултати накратко

Peptide Coated Platinum Nanoparticles as Antitumor Agents

Cisplatin is an efficient chemotherapeutic drug, yet it suffers from two main disadvantages: evolving drug resistance and relatively high toxicity. There is therefore a need to develop successful candidates for anticancer treatments with reduced toxicity and improved activity. One of the latest approaches for dealing with these drawbacks has been the development of platinum nanoparticles (PtNPs) as a source of Pt(II) ions. However, this solution is far from effective, mainly due to obstacles in cancer cell targeting and a lack of nuclear penetration. The overall objectives of this project were to form PtNPs in a straight forward process that have high cytotoxicity and tumor selectivity.

Текст от CORDIS, на английски · Данни: CORDIS, © Европейски съюз

Цел на проекта

Cisplatin is an efficient chemotherapeutic drug, yet it suffers from two main disadvantages: evolving drug resistance and relatively high toxicity. One of the latest approaches for dealing with these drawbacks has been the development of platinum nanoparticles (PtNPs) as a Pt(II) ion source. However, this solution is far from effective, mainly due to obstacles in cancer-cell targeting and a lack of nuclear penetration. The Wennemers group developed a combinatorial screening for the identification of peptides that allow for the formation of metal nanoparticles. The identified peptides control the geometric parameters of the nanoparticles and stabilize them in the aqueous environment. This proposed research aims to investigate the functionalized peptide-coated PtNPs as potential antitumor agents. We will use this combinatorial assay for the controlled formation of small PtNPs. The mechanism of nanoparticle formation will be extensively investigated, including full structural NMR analyses, thermodynamic and kinetic studies, all with the intention of providing insights into how the size-controlled PtNP formation is achieved. The major challenge will be to find the ideal, additive, peptide-based modification for specifically translocating PtNPs into the cancer cell nucleus. We believe that this potentially pro-drug will be inactive in the extracellular environment due to the presence of inert Pt(0) that will be oxidized by the high levels of hydrogen peroxide in cancer cells to Pt(II) ions. Therefore, in vitro cytotoxicity will be studied, as well as toxicity and metal accumulation in healthy cell lines to discover anti-cancerogenic peptide-coated PtNPs.

Оригинален текст от CORDIS (на английски).

Участници

EIDGENOESSISCHE TECHNISCHE HOCHSCHULE ZUERICH · ZuerichКоординаторШвейцария