H2020Индивидуална стипендия2017–2019

DrugCrops · Drought discovery to improve drought tolerance in crops

„Хоризонт 2020“ — Действия „Мария Склодовска-Кюри“

Период: 2017-03-03 → 2019-03-02
Финансиране от ЕС: 158 122 €
Участници: 1
Схема: MSCA-IF

Линиите свързват координатора с партньорите.

Накратко на български

Рецепторите на хормона абсцисова киселина при царевицата и просата се анализират, за да се открият молекули, които активират защитата на растенията. Това помага за подобряване на устойчивостта на културите към суша в условията на климатичните промени.

Този кратък обзор е генериран от изкуствен интелект

Кратко обяснение, генерирано от езиков модел по текста на CORDIS. Оригиналът е по-долу.

Резултати накратко

Drought discovery to improve drought tolerance in crops

In order to produce food in a sustainable way for an additional 2 billion people by 2050, crop yield needs to increase significantly. This becomes even more important in the face of climate change, where predictions indicate an increase in extreme droughts in important agricultural areas worldwide. The plant hormone abscisic acid, protect plants against these stresses by coordinating adaptative responses to reinforce plant stress tolerance. In the last years, the major class of ABA receptors has been described and extensive structural data is available for the receptors of the dicot model plant Arabidopsis thaliana. However, in crops, that provide more than 50% of the diet worldwide, this knowledge is very limited. The goal of DrugCrops is to generate and use data on the ABA receptors in the model crop plant Setaria viridis (Setaria) and in maize to discover novel ABA receptor agonists to improve drought resistance using small molecules. The Experienced Researcher (ER) has been working in collaboration with different partner research organizations to fulfill the following objectives: -Objective 1: Identification and characterization of the ABA signaling core module in Maize and Setaria. The different components of the ABA signaling core module have not been characterized in detail in maize or Setaria. Here, we will identify and characterize i) the ABA receptors, ii) the PP2Cs and iii) the SnRK2s involved in the ABA signaling core for both Maize and Setaria. -Objective 2: Development of new ABA agonsits. We will use high-throughput screening and virtual docking methods to obtain the first set of small molecules able to activate stress tolerance in crops. The best agonists will be characterized in greenhouse experiments to assess their activity on stress tolerance. -Objective 3: Structural analysis of PYR/PYL/RCAR proteins in complex with synthetic agonists. The crystal structure ligand-receptor will be generated for the best 2 compounds. This data has the potential to be used by the ER in the future to design novel ABA agonists and will help him to establish his own laboratory.

Текст от CORDIS, на английски · Данни: CORDIS, © Европейски съюз

Цел на проекта

Feeding 9 billion people by 2040 in a context of water shortage poses a critical challenge for agricultural practices, particularly under recurrent drought periods. The so-called Blue Revolution -evaluated by UN as an urgent priority- calls to develop innovative solutions to grow staple food crops in water-limited conditions. Increasing temperatures and reduced precipitation have severely impaired crop yields. Plants can be protected against these stresses by the action of the hormone abscisic acid (ABA), which orchestrates a multitude of adaptive responses that enhance plant survival. The major class of ABA receptors has been characterized and structural data are available for the receptors of the model plant Arabidopsis thaliana. However, in crops that provide more than 50% of the diet worldwide, this knowledge is limited. The goal of DrugCrops is to generate and exploit biochemical and structural data of the ABA receptors in the model crop plant Setaria viridis and in maize to develop novel ABA receptor agonists in order to enhance drought tolerance using small molecules. Towards this translational and multidisciplinary goal, we propose the use of high throughput technologies, X-ray crystallographic, chemical and genetic approaches to dissect the mechanism by which agonists engage and activate their receptors. This information will be leveraged for the design of new chemicals that can be used to control abiotic stress tolerance in crop plants. The ER will work in collaboration with different partner research organizations with recognized expertise in ABA signaling, chemical and structural biology that collectively bring experience ranging from big pharma drug discovery to the genetic engineering of drought tolerant crops. As a result, both the ER and Host could obtain new molecules for plant biotechnology in the field of plant drought tolerance, boosting knowledge-based bioeconomy in the EU and ER´s possibilities to reach a position in research.

Оригинален текст от CORDIS (на английски).

Участници

AGENCIA ESTATAL CONSEJO SUPERIOR DE INVESTIGACIONES CIENTIFICAS · MadridКоординаторИспания