H2020Индивидуална стипендия2016–2018

NIR-BIO-FLU · Bio-conjugatable and Bio-responsive Near Infrared Fluorochromes

„Хоризонт 2020“ — Действия „Мария Склодовска-Кюри“

Период: 2016-03-01 → 2018-02-28
Финансиране от ЕС: 175 866 €
Участници: 1
Схема: MSCA-IF-EF-ST

Линиите свързват координатора с партньорите.

Накратко на български

Нови флуоресцентни маркери в близкия инфрачервен спектър се разработват за по-лесно откриване на ракови тъкани и метастази в лимфните възли. Те могат да помогнат на хирурзите да разграничат по-точно здравите от болните тъкани по време на операции.

Този кратък обзор е генериран от изкуствен интелект

Кратко обяснение, генерирано от езиков модел по текста на CORDIS. Оригиналът е по-долу.

Резултати накратко

Bio-conjugatable and Bio-responsive Near Infrared Fluorochromes

The development of novel imaging agents to assist in the detection of several kinds of cancer diseases is one actual challenge of the scientific community due cancer remains as the major public health issue in Europe because of its high prevalence, morbidity, and mortality. In this aspect, near-infrared (NIR) fluorescence imaging has been clinically used in cancer targeting and imaging due to deep photon penetration in tissue (10-15 nm), minimizes photo-damage to biological samples and produces low background auto-fluorescence from biomolecules present in living systems. , It supposes a huge advance in clinical NIR-fluorescence imaging could be exploited to assist surgeons to distinguish between malignant and normal tissues in the challenging environment of an operating theatre. For example, over 50% of all cancerous conditions are first treated with surgery with the only guide available to the surgeon being their experience. It is currently not possible to differentiate between non-diseased lymph nodes from those that contain metastatic cancer lesions. If improvements to surgical outcomes utilizing the advantages of NIR-fluorescence could be achieved the improvement of societal health in Europe would be far-reaching. Boron-chelated aza-dipyrromethenes (NIR-AZA) is an easily synthesizable novel NIR-fluorophore class with suitable properties, as strong absorptions and emissions within the NIR spectral, highly photostability and good quantum yields, to be employed in biological imaging (Figure 1). Consider the above mentioned, the objectives of this project involve: 1. Synthesis and characterization of new bio-responsive and bionconjugable NIR-AZA 2. Desing and synthesis of NIR-AZA to assist in the lymphnode detection. 3. Develop new cell membrane responsive NIR-Fluorescent probe 4. Delopvement of new strategies for the synthesis of NIR-AZA

Текст от CORDIS, на английски · Данни: CORDIS, © Европейски съюз

Цел на проекта

Near-infrared (NIR) fluorescence molecular imaging is a supra-discipline that enables visualisation of cellular function and real-time tracking of molecular processes in living organisms without perturbing them. If exploited to its maximum potential, NIR-fluorescence could have hugely positive impact for early stage diagnosis of diseases such as cancer, neurological and cardiovascular disease, the optimisation of preclinical and clinical tests for new medication and act as a real-time guide during surgery. This proposal seeks support for a MSC Fellowship to develop new biologically responsive off to on switchable NIR fluorochromes i.e. NIR fluorescent probes that respond selectively to cellular uptake and with specificity for cancer cells achieved through bio-conjugation with proven targeting agents. Specifically, the focus is on the design, synthesis, photophysical characterisation, in vitro cell imaging and preliminary in vivo assessment of such probes for the ultimate in vivo detection of colorectal cancer metastasis. Colorectal cancer is the third most common cancer and remains a major public health issue in Europe because of its high prevalence, morbidity, and mortality. The synergetic combination of the host laboratory’s interdisciplinary expertise, the host institution’s ability to deliver a comprehensive training program and the applicant’s excellent prior Ph.D. training experience in developing fluorescence chromophores with function-tailored photophysical properties is the perfect match to deliver the project goals and provide the stepping stone to independent researcher for the applicant.

Оригинален текст от CORDIS (на английски).

Участници

ROYAL COLLEGE OF SURGEONS IN IRELAND · DUBLIN 2КоординаторИрландия