REFOLDAMER · Communication through Polarity-Switchable Foldamers
„Хоризонт 2020“ — Действия „Мария Склодовска-Кюри“
- Период
- 2016-04-04 → 2018-04-03
- Финансиране от ЕС
- 183 455 €
- Участници
- 1
- Схема
- MSCA-IF-EF-ST
Линиите свързват координатора с партньорите.
Накратко на български
Синтетични молекули с променлива форма, подобни на ДНК, се тестват за предаване на информация от единия си край до другия. Успехът в тази област може да помогне за по-доброто контролиране на биологичните системи и борбата с болести.
Кратко обяснение, генерирано от езиков модел по текста на CORDIS. Оригиналът е по-долу.
Резултати накратко
Communication through Polarity-Switchable Foldamers
Nature uses molecules that can change shape to communicate information. In this project we looked to develop artificial methods that could achieve related outcomes more generally, using synthetic compounds. We set out to explore simple chain molecules that can change shape, and to induce them to do this by borrowing some ideas from the structure of DNA. Ultimately, success could lead to new ways of controlling the function of biological systems, ie curing diseases. Our overall objective was to indiuce a single molecule to change shape, and for that change in shape to be transmitted from one end of the molecule to the other. It turned olut that this was a difficult task, and the project made significant discoveries that helped us along the route to this aim, but further work is needed to reach the target. We can conclude from the work so far that selective binding-induced changes in shape are possible, but that communicating that shape change through the molecule is more difficult if the molecule already has a favoured arrangement.
Текст от CORDIS, на английски · Данни: CORDIS, © Европейски съюз
Цел на проекта
We propose to develop a new, artificial but bio-inspired mechanism for communicating information in chemical systems, by using the potential for hydrogen-bond reorganisation of novel dynamic 'refoldable foldamers', combined with biology's information storage mechanisms. Biological information is encoded in DNA or RNA by two dimensional arrangements of hydrogen bond donors and acceptors in nucleotide sequences: we will innovate nanoscale communication devices that read information encoded in this way, and translate it directly into a chemical feature (catalytic activity, ligand-binding ability) at a site remote from the source of information. Conceptually we shall telescope the biological processes of transcription and translation into a single conformational event in a single molecule.We will develop a new class of polarity-reversible foldamers as artificial receptors to translate information stored in hydrogen bonding patterns into a local conformational preference. The preference will be communicated the full length of the foldamer by means of a global change in shape, and used to define the detailed structure and hence spectroscopic and chemical properties at another site in the molecule. Those devices will mimic biology’s ability to communicate information in a manner reminiscent of the G-protein coupled receptor. Dynamic foldamer conformational switching will be based on reversible hydrogen-bond polarity rather than on helical screw sense switching recently used by Clayden to carry information: reversal in directionality of hydrogen bond networks has not yet been exploited.Success would open up a new area of science at the boundary of synthetic chemistry and biology, facilitating new developments in as-yet untapped applications of dynamic foldamers, improving European Science competitiveness. Transfer of cutting edge knowledge to a European scientist of outstanding potential will greatly enhance his career horizons.
Оригинален текст от CORDIS (на английски).
Участници
- UNIVERSITY OF BRISTOL · BRISTOLКоординаторОбединеното кралство
Връзки
Данни: CORDIS, © Европейски съюз