SMART-BONE · Smart electroactive 3D models of osteoregeneration
„Хоризонт 2020“ — Действия „Мария Склодовска-Кюри“
- Период
- 2016-09-01 → 2018-08-31
- Финансиране от ЕС
- 173 076 €
- Участници
- 2
- Схема
- MSCA-IF-EF-ST
Линиите свързват координатора с партньорите.
Накратко на български
Електроактивни 3D структури се тестват като основа за отглеждане и стимулиране на стволови клетки за възстановяване на костна тъкан. Това помага за създаването на по-достъпни и съвместими с тялото импланти, които да намалят разходите и трудностите при лечението на фрактури.
Кратко обяснение, генерирано от езиков модел по текста на CORDIS. Оригиналът е по-долу.
Резултати накратко
Smart electroactive 3D models of osteoregeneration
In the European Union alone, the annual number of bone fractures is projected to reach 4.5 million in 2025.1 In the EU in 2010 the costs of treating incident fractures connected solely with osteoporosis amounted to about €24 billion. Despite the advances in implant technology, grafts prepared using bone extracted from the patient to fill the bone defect are the only material reported so far to retain any significant efficacy in sustaining new bone formation.2 However, the aging worldwide population and increased life expectancy call for a different answer to the growing need for effective implants. The possibility to have easily available and effective bone regeneration implants that are biocompatible, and with low inflammatory response is a crucial goal for the research community, both in material science and orthopedics, translating to major benefits for future patients. The three main objectives of the SMART-BONE project are to: - Develop electroactive 3D-scaffolds as substrate for hosting BM-MScs and NCSCs culture and stimulation, - Implement an OECT specifically recognizing analytes related to osteogenesis and vasculogenesis, - Monitor stem cells fate upon electrical stimulation with the OECT integrating the 3D-scaffolds.
Текст от CORDIS, на английски · Данни: CORDIS, © Европейски съюз
Цел на проекта
In the European Union alone, the annual number of bone fractures is projected to reach 4.5 million in 2025. Despite the advances in implant technology, grafts prepared using bone extracted from the patient to fill the bone defect are the only material reported so far to retain any significant efficacy in sustaining new bone formation. However, the aging worldwide population and increased life expectancy call for a different answer to the growing need for effective implants for bone fracture healing. The 3D-BONE project will develop an in vitro 3D model to investigate electrical stimulation of stem cells based on biocompatible electroactive 3D scaffolds produced by the ice-templating technique. Electrical stimulation has been shown to positively affect stem cells differentiation into both bone- and vessels-forming cells. One of the key novelty of the 3D-BONE project is the use of human neural crest-derived stem cells (NCSCs). The study of this system in vitro will contribute to increasing the knowledge on a cell population that has the remarkable characteristic of preserving their potentialities to differentiate towards multiple lineages also in the adult. They can thus be isolated from the patient in need of the bone graft, with no need of external donors. Cells’ response to the applied electrical stimulus will be investigated using an organic electrochemical transistor (OECT) that will be integrated in the developed device and will allow for label-free monitoring of cells through an electronic readout. Altogether, the results of these studies will prove beneficial to increase the knowledge on electrically stimulated stem cells differentiation, providing new key tools for the development of implants to be successfully used in critical size defects healing.
Оригинален текст от CORDIS (на английски).
Участници
- THE CHANCELLOR MASTERS AND SCHOLARS OF THE UNIVERSITY OF CAMBRIDGE · CAMBRIDGEКоординаторОбединеното кралство
- INSTITUT MINES-TELECOM · PalaiseauФранция
Връзки
Данни: CORDIS, © Европейски съюз