H2020Индивидуална стипендия2016–2018

EpiHope · Epigenetic biomarkers for prediction of vascular complications and response to treatment in subjects with diabetes

„Хоризонт 2020“ — Действия „Мария Склодовска-Кюри“

Период: 2016-06-01 → 2018-05-31
Финансиране от ЕС: 173 857 €
Участници: 1
Схема: MSCA-IF-EF-ST

Линиите свързват координатора с партньорите.

Накратко на български

Епигенетични маркери в кръвта се анализират, за да се предвиди дали пациенти с диабет тип 2 ще реагират на лечение с метформин или рискуват от инсулт и инфаркт. Това помага за избор на подходящо лекарство и ранна превенция на сърдечно-съдови усложнения.

Този кратък обзор е генериран от изкуствен интелект

Кратко обяснение, генерирано от езиков модел по текста на CORDIS. Оригиналът е по-долу.

Резултати накратко

Epigenetic biomarkers for prediction of vascular complications and response to treatment in subjects with diabetes

Metformin is the first-line therapy of type 2 diabetes (T2D), but among T2D patients, ~30% are classified as glycemic non-responders. Currently no clinical phenotype successfully predicts the glycemic response to metformin. Therefore, our aim was to identify blood-based epigenetic biomarkers that successfully predicts metformin response in drug-naïve T2D patients. This research is of high importance since the epigenetic biomarkers could be used in the clinics in all newly T2D patients to discriminate which diabetics cannot receive metformin since they will not respond to this drug. This biomarker kit will progress personalized treatment for T2D using pharmacoepigenetics for the prediction of glycemic response to metformin treatment in newly diagnosed patients with T2D. Therefore, it will be essential for clinical decision making in T2D treatment. On the other hand, T2D increases the risk for cardiovascular disease (CVD) and mortality. However, it is not known why some diabetic individuals develop these complications whereas others not. Hence, we aimed to identify blood-based epigenetic biomarkers that successfully predict coronary events and stroke in T2D subjects. Notably, our epigenetic biomarkers will provide a useful tool to identify T2D subjects at high risk of developing CVD to prevent at an early stage the progression to a macrovascular event. In fact, prevention is possible since early intensive glycemic control of T2D reduce in the long-term the number of macrovascular complications. Overall, the identified epigenetic biomarkers of clinical relevance from this project predicting metformin response and macrovascular complications in people with T2D could provide a valuable tool for personalized medicine.

Текст от CORDIS, на английски · Данни: CORDIS, © Европейски съюз

Цел на проекта

Type 2 diabetes (T2D) is one of the leading causes of death through its deleterious effects on cardiovascular disease (CVD). The complications of T2D can be reduced through early and appropriate preventive and therapeutic interventions. Several studies suggest that epigenetics may play a key role in the pathogenesis of these diseases. However, additional studies are needed to improve primary prevention and treatment of T2D and vascular complications. Our overall objective is to identify novel epigenetic biomarkers of clinical relevance that predict, monitor progression and forecast response to treatment of T2D and CVD. First we aim to identify clinically useful epigenetic biomarkers (DNA methylation will be analysed genome-wide) that can predict the glycaemic response to metformin treatment and future risk of CVD in newly diagnosed T2D patients recruited from ANDIS cohort. Second, the most efficient epigenetic biomarkers identified will be validated in T2D patients from ANDIS using pyrosequencing. Third, we aim to make combined predictive risk scores with our novel epigenetic biomarkers, genetic and clinical risk factors to assess risk for CVD. Finally, we will test functional characterization of the validated epigenetic biomarkers in target tissues from T2D patients, and in vitro follow-up studies will be developed. This project represents an outstanding opportunity for personalized treatment for T2D, proposing for the first time pharmacoepigenetics in this field, and also for the development of a panel of high-quality epigenetic biomarkers together with combined risk scores, aiming to give a new reliable clinical tool for early prevention of CVD in T2D patients. Notably, epigenetic modifications can be manipulated more readily than genomic mutations, and thereby has much of potential for pharmacological applications. In summary, the findings of robust epigenetic biomarkers will optimize the therapeutics of T2D and the preventive care of vascular complications.

Оригинален текст от CORDIS (на английски).

Участници

LUNDS UNIVERSITET · LundКоординаторШвеция