H2020Индивидуална стипендия2016–2018

AGE-MEMORY · Identification of insulin signalling factors that delay age-related memory impairment

„Хоризонт 2020“ — Действия „Мария Склодовска-Кюри“

Период: 2016-06-01 → 2018-05-31
Финансиране от ЕС: 164 653 €
Участници: 1
Схема: MSCA-IF-EF-ST

Линиите свързват координатора с партньорите.

Накратко на български

Инсулиновата сигнализация се изучава, за да се разбере кактое влиянието ѝ върху паметта и ученето при стареенето. Това е важно, защото идентифицирането на тези механизми може да помогне за разработването на бъдещи терапии срещу когнитивния спад.

Този кратък обзор е генериран от изкуствен интелект

Кратко обяснение, генерирано от езиков модел по текста на CORDIS. Оригиналът е по-долу.

Резултати накратко

Identification of insulin signalling factors that delay age-related memory impairment

Human's life expectancy is continuously increasing and and with an ever-increasing proportion of elderly people, novel treatments of age-related diseases are necessary. One of the first systems that deteriorate with ageing is cognitive function, causing learning, memory, concentrating and decision making disabilities. It affects 18.5% of individuals over -50's and it can start during the mid-twenties. Age-related memory impairment is a major symptom of Alzheimer's disease and so far it is not curable. Identification of evolutionarily conserved pathways that enhance ageing in animals can be pharmacological targets for relative treatments in future. Model organisms share common mechanisms that boost or delay ageing, such as the insulin signalling (IIS)and the TOR signalling, which is regulated by IIS signalling. Reduction of IIS and TOR extend lifespan in animals and can improve health, even in humans. Also, increasing evidence suggests that IIS might affect brain ageing. thus IIS manipulation might delay age-related memory impairment. The overall objectives of this project was to study the effect of lowered IIS on learning and memory through ageing, the identification of IIS components that govern learning and memory decline and the characterisation of the mechanisms/factors through which IIS affects memory decline.

Текст от CORDIS, на английски · Данни: CORDIS, © Европейски съюз

Цел на проекта

Elucidation of the biological mechanisms that govern ageing can facilitate the discovery of evolutionarily conserved factors, which denominate physiological deterioration in humans. Here we will study the effect of insulin/insulin like growth factor signalling (IIS), shown to delay ageing in several organisms, on age-related memory impairment (AMI). We will use both C. elegans and Drosophila as experimental platforms, to test evolutionarily conservation of findings. Longevity combined with memory experiments will be applied in several IIS mutants. We will dissect IIS to find putative mediators of IIS effects on cognitive function. To identify relative mechanisms we will measure activity of known AMI regulators in IIS mutants. Depending on our results, our study will expand on transcription profiling worms and flies IIS mutants of different ages. Neuronal genes differentially affected by IIS will be further studied. We will use novel imaging techniques to characterize morphological changes that occur through ageing in the nervous system. This study is a first step to identify universal mechanisms that underlay cognitive function decline. Pharmacological manipulation of such mechanisms could delay AMI in humans.

Оригинален текст от CORDIS (на английски).

Участници

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