H2020Съфинансиране2016–2021

ALERT · Local Training Network on Novel Tailor-Made Antimicrobials and Delivery Strategies From Synthesis towards Clinical Applications

„Хоризонт 2020“ — Действия „Мария Склодовска-Кюри“

Период: 2016-05-01 → 2021-04-30
Финансиране от ЕС: 1 988 160 €
Участници: 1
Схема: MSCA-COFUND-DP

Линиите свързват координатора с партньорите.

Накратко на български

Нови антимикробни вещества, създадени чрез химичен синтез, биотехнологии и нанотехнологии, се тестват за борба с бактерии. Това помага за справянето с бактериите, които са станали устойчиви на стандартните антибиотици.

Този кратък обзор е генериран от изкуствен интелект

Кратко обяснение, генерирано от езиков модел по текста на CORDIS. Оригиналът е по-долу.

Резултати накратко

Local Training Network on Novel Tailor-Made Antimicrobials and Delivery Strategies From Synthesis towards Clinical Applications

The development of antibiotics almost completely extinguished infectious diseases, such as tuberculosis, pneumonia, typhoid fever and meningitis in the 19th and 20th centuries. In the 21st century, however, the overuse of antibiotics led to the emergence of multidrug resistant (MDR) bacteria. Therefore, besides classical antibiotic development, alternative strategies employing modern tools from nanotechnology or synthetic biology need to be pursued. The local training network ALERT addresses this challenge by establishing a dedicated doctoral training program with an international, interdisciplinary and inter-sectoral focus. Nineteen excellent Early Stage Researchers (ERSs) conducted cutting-edge research projects in the field of antimicrobials and have been trained in specialist advanced courses, training schools and other networking activities. ALERT has contributed to the major goal to overcome the thread of MDR bacteria through the development of novel antimicrobial drug candidates by chemical, biotechnological and nanotechnological synthesis and the subsequent testing of promising candidates in vivo. The objectives have been distributed into four tasks. Task 1 was focused on methods to shorten the time for identifying and preparing novel antimicrobial molecules using innovative chemical synthesis approaches. Task 2 was dedicated to the development of new antimicrobials at a biotechnological level, exploiting rational design and synthetic biology construction principles. In addition, task 3 addressed nanotechnology approaches to create new antimicrobials that can locally fight pathogens. Task 4 covered the in vivo testing of promising antimicrobial drug candidates resulting from Tasks 1-3.

Текст от CORDIS, на английски · Данни: CORDIS, © Европейски съюз

Цел на проекта

The current overuse of antibiotics is leading to the emergence of multidrug resistant (MDR) bacteria. These MDR pathogens continue to evolve at a terrifying rate and confer resistance to most or all presently available antibacterial treatments. Antimicrobial resistance is an eminent global problem that calls for an integrated approach that surpasses national borders, sectors, and disciplines. The COFUND ALERT programme addresses this call by establishing a dedicated doctoral training programme with an international, interdisciplinary and inter-sectoral focus. Nineteen excellent Early Stage Researchers (ESRs) will be employed at the University of Groningen (RUG). ALERT is based at RUG but is tightly connected with multiple international academic and private partner organisations, each providing complementary research or training. ALERT aims to develop the best practices in high quality training and research. ALERT achieves this through advanced multidisciplinary research training extended with development of dedicated transferable and entrepreneurial skills. ESRs will develop novel antimicrobial drug candidates through chemical, biotechnological and nanotechnological synthesis and subsequent in vivo testing. All ALERT Principal Investigators have ample experience with supervising PhD students, which ensures an attractive and vibrant research environment for the ESRs. In addition, access to excellent modern research facilities is guaranteed. Thus, the ALERT programme creates an optimal research and training environment that is far greater than the sum of its individual parts. ALERT’s long-term ambitions are to establish a strong and coherent international network that links together highly skilled young researchers as well as established scientists, who far beyond the funding period will continue to inspire each other to excel in antimicrobial resistance research in order to tackle the antimicrobial challenge.

Оригинален текст от CORDIS (на английски).

Участници

RIJKSUNIVERSITEIT GRONINGEN · GroningenКоординаторНидерландия