H2020Индивидуална стипендия2016–2018

STRAVIR · Role of the stroma-derived ‘alarmin’ IL-33 in anti-viral immunity

„Хоризонт 2020“ — Действия „Мария Склодовска-Кюри“

Период: 2016-10-01 → 2018-09-30
Финансиране от ЕС: 175 420 €
Участници: 1
Схема: MSCA-IF-EF-ST

Линиите свързват координатора с партньорите.

Накратко на български

Протеинът IL-33 действа като сигнал за опасност, който активира имунните клетки при вирусна инфекция. Разбирането на това кои клетки го произвеждат и как се регулира, помага за изясняване на механизмите за защита на организма срещу вируси.

Този кратък обзор е генериран от изкуствен интелект

Кратко обяснение, генерирано от езиков модел по текста на CORDIS. Оригиналът е по-долу.

Резултати накратко

Role of the stroma-derived ‘alarmin’ IL-33 in anti-viral immunity

Our immune system has evolved sophisticated mechanisms to defend our body against harmful infections produced by various pathogens including bacteria and viruses. Upon viral infection, stressed or damaged cells can release alarmins like interleukin-33 (IL-33) that act as endogenous danger signals alerting innate and adaptive immune cells. IL-33 coming from a non-hematopoietic source has been identified as important factor driving anti-viral CD8+ T cell expansion, however the cell type producing it and the signals leading to their release are still poorly known. This project aims to identify and characterize the cellular source of IL-33, to eventually gain a better understanding of the mechanisms regulating protective immune responses to viruses. To this end, the research focused on the following objectives: • Objective 1: Identification and characterization of IL-33 producing cells in secondary lymphoid organs during viral infection. • Objective 2: Identification of the time window and signals regulating IL-33 production and secretion from the relevant stromal cells found in infected secondary lymphoid organs • Objective 3: Characterization of the effects of IL-33 on the expansion, migration and function of virus-specific T cells

Текст от CORDIS, на английски · Данни: CORDIS, © Европейски съюз

Цел на проекта

There is increasing awareness that the recently identified cytokine IL-33 is playing a key role in multiple types of infections and pathologies. It has been recently demonstrated that IL-33 is crucial for mounting an efficient immune response against viral infections as it strongly enhances T cell responses with lack of IL-33 leading to failure in virus control. IL-33 production by stromal cells in lymph nodes (LN) and spleen is crucial for efficient viral clearance, however, the precise cellular source and signals involved in secretion of this nuclear alarmin during viral infection are unknown. In addition, it is poorly understood how this cytokine controls antiviral CD8 T cell function. To determine the cellular source of IL-33 during viral infections, we will assess IL-33 production by the different types of stromal cells present in lymph nodes and spleen during acute viral infection. The Luther lab has the expertise and state-of-the-art facilities to perform in situ characterization and in vivo analysis of stromal cell subsets present in these organs, allowing for the identification of the IL-33 producing population. Using IL-33GFP/+ mice will facilitate the identification of the cellular source of IL-33 during viral infections. Moreover, using in vitro cultures we will study the signals regulating IL-33 release as well as its role in T cells function. All together, the work described aims to increase our understanding of the mechanisms underlying stromal IL-33 secretion and its effects on antiviral T cell responses and wishes to broaden our knowledge on the role of stroma cells regulating immune responses. Importantly, this work could have future implications for antiviral treatments, including the development of better strategies for antiviral treatments including vaccines or immunotherapy.

Оригинален текст от CORDIS (на английски).

Участници

UNIVERSITE DE LAUSANNE · LAUSANNEКоординаторШвейцария