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КартаВръзкиТемиБългарияНощта (K-TRIO)Мария Склодовска-КюриЗа ученициЗа учителиМетодологияИзненадай ме
H2020Докторантска мрежа2016–2020

OcuTher · Educational Network in Ocular Drug Delivery and Therapeutics

„Хоризонт 2020“ — Действия „Мария Склодовска-Кюри“

Период
2016-11-01 → 2020-10-31
Финансиране от ЕС
3 933 729 €
Участници
18
Схема
MSCA-ITN-ETN

Линиите свързват координатора с партньорите.

Накратко на български

Нови методи за доставяне на лекарства до задната част на окото се тестват при заболявания като глаукома и диабетна ретинопатия. Това е важно, защото сегашните терапии често не достигат ефективно до целевите зони, което затруднява развитието на фармакологични лечения.

Този кратък обзор е генериран от изкуствен интелект

Кратко обяснение, генерирано от езиков модел по текста на CORDIS. Оригиналът е по-долу.

Резултати накратко

Educational Network in Ocular Drug Delivery and Therapeutics

Ocular drug therapy, especially the treatment of diseases affecting the posterior eye segment, is hampered by the ineffective drug delivery to the target sites. Therefore, development of drugs against age-related macular degeneration, glaucomatous retinal degeneration, diabetic retinopathies and inherited retinal degenerations has been slow, and most retinal diseases are still without pharmacological treatments. Lack of treatments is related to the problems of drug delivery and lack of systematic tools for ocular drug development. OCUTHER brings together all the necessary expertise for preclinical development of retinal drug treatments, including chemistry, drug delivery system design, experimental and computational pharmacokinetics, and ophthalmology. The project integrates together combined efforts of 9 beneficiaries from academia and industry, 2 academic, and 7 non-academic partner organisations. Our objectives are to develop new experimental and computational tools for ocular drug development, and test new potential regenerative treatments for retinal diseases, including both drugs and novel delivery systems. OCUTHER will train the next generation of scientists in this field by offering an extensive joint training programme to 15 ESRs. The project focuses on promoting scientific excellence and exploits the specific research and commercial expertise and infrastructure of the OCUTHER network as a whole. The exposure to all elements of ocular drug development enables OCUTHER to translate expertise from all disciplines to the ESRs and educate the future scientists in the field of ocular drug development.

Текст от CORDIS, на английски · Данни: CORDIS, © Европейски съюз

Цел на проекта

Ocular drug development has transformed from niche area to a major field in drug development in which many companies, including European big pharma has entered recently. Ocular drug development is a unique field in terms of drug targets and end-points of activity, local drug administration routes, tissue barriers and pharmacokinetics, drug delivery and formulation challenges and local toxicity issues. These issues are slowing down the development of drugs for the unmet needs in ophthalmology. The main objective of the proposal is to educate experts of preclinical ocular R&D to facilitate the success of European pharmaceutical industry and research community. This objective will be reached by joining forces of the leading European academic and industrial researchers in ophthalmology, materials science and nanomedicine, drug delivery and targeting, and systems pharmacology. We shall educate 15 Early Stage Researchers in a network where they will receive tailored, multi-disciplinary and inter-sectoral education in preclinical ocular drug development. The thesis projects are directed to the drug treatment of retinal diseases, the major challenge in the field. The proposal combines new drug candidates from the experts of ophthalmology, innovative drug delivery technologies from pharmaceutical scientists and companies, and modern in vitro, in silico and in vivo methods from various partners. The thesis projects include secondments in academic and industrial partner laboratories and course programme that encompasses the relevant fields in ocular drug development. Therefore, this proposal presents unique combination of innovation and education in the field with obvious need for such education. The ESRs and other outcomes of this project will greatly benefit the future competitiveness of European science and industry in this field of expanding importance.

Оригинален текст от CORDIS (на английски).

Участници

Връзки

Данни: CORDIS, © Европейски съюз