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КартаВръзкиТемиБългарияНощта (K-TRIO)Мария Склодовска-КюриЗа ученициЗа учителиМетодологияИзненадай ме
H2020Докторантска мрежа2017–2021

PATHSENSE · Training Network to Understand and Exploit Mechanisms of Sensory Perception in Bacteria

„Хоризонт 2020“ — Действия „Мария Склодовска-Кюри“

Период
2017-04-01 → 2021-03-31
Финансиране от ЕС
3 381 742 €
Участници
15
Схема
MSCA-ITN-ETN

Линиите свързват координатора с партньорите.

Накратко на български

Молекулярните механизми на сетивното възприятие при бактериите, като например работата на органелата стресозом, се изучават в този проект. Разбирането на начина, по който патогените усещат заплахите в средата си, помага да се открият слабите им места.

Този кратък обзор е генериран от изкуствен интелект

Кратко обяснение, генерирано от езиков модел по текста на CORDIS. Оригиналът е по-долу.

Резултати накратко

Training Network to Understand and Exploit Mechanisms of Sensory Perception in Bacteria

The PATHSENSE (Pathogen Sensing) ETN tackled a highly ambitious scientific project, focusing on the molecular mechanisms of sensory perception in bacterial pathogens. We focussed on a complex sensory organelle that is widespread in the bacterial tree-of-life but little understood; the stressosome. The stressosome allows bacteria to sense threats in their environment and activate a protective response, so it represents a potential Achilles heel in pathogenic microbes. We established an innovative doctoral training programme that has trained 13 early stage researchers and delivered high-impact scientific outputs. The project has allowed inter-sectoral mobility of the ESRs across 7 European countries (IE, UK, DE, ES, NL, CH, SE) to make full use of the complementary skills available at each of the host institutions [10 leading Universities, 1 public research institution, 4 companies (from spin-off to large multi-national) and 1 food safety governmental authority].

Текст от CORDIS, на английски · Данни: CORDIS, © Европейски съюз

Цел на проекта

The PATHSENSE (Pathogen Sensing) ETN will bring together an interdisciplinary team of world-leading researchers from Europe to tackle a highly ambitious scientific project, focusing on the molecular mechanisms of sensory perception in bacterial pathogens. PATHSENSE will establish an innovative doctoral training programme that will deliver 13 PhD graduates and high-impact scientific outputs. The relationship between molecular structures and biological function is central to understanding any living system; however the research methodologies required to unravel these relationships are often complex and fast-changing. The team participating in this Network has the infrastructure and track-record to train ESRs in these state-of-the art methodologies, including structural biology, proteomics & protein biochemistry, molecular biology, bacterial genetics, food microbiology, mathematical modelling, cell biology, microscopy and comparative genomics. PATHSENSE will investigate the poorly understood structure-function relationships that exist within a large multi-protein complex called a “stressosome”, which acts as a sensory organelle in bacteria. The project will involve extensive inter-sectoral mobility of the ESRs across 7 EU countries to make full use of the complementary skills available at each of the hosting institutions. The inter-sectoral Network comprises 8 leading Universities, 1 public research institution, 4 companies (from spin-off to large multi-national) and 1 governmental agency. A major objective of this Network will be to exploit the fundamental research to develop novel antimicrobial treatments that have applications in the food and public health sectors. This project will deliver high-impact science, 13 highly-trained innovative researchers and will produce a long-lasting inter-sectoral network of collaborators who will continue to work together to exploit fundamental research for the socio-economic benefit of Europe.

Оригинален текст от CORDIS (на английски).

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Връзки

Данни: CORDIS, © Европейски съюз