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КартаВръзкиТемиБългарияНощта (K-TRIO)Мария Склодовска-КюриЗа ученициЗа учителиМетодологияИзненадай ме
H2020Докторантска мрежа2016–2021

REMIX · Regulation of mitochondrial expression

„Хоризонт 2020“ — Действия „Мария Склодовска-Кюри“

Период
2016-10-01 → 2021-01-31
Финансиране от ЕС
3 920 630 €
Участници
10
Схема
MSCA-ITN-ETN

Линиите свързват координатора с партньорите.

Накратко на български

Молекулярните механизми, чрез които ядрото и митохондриите координират експресията на гените си, са в центъра на анализа. Разбирането на тези процеси помага да се обясни развитието на различни човешки заболявания и процесите на стареене.

Този кратък обзор е генериран от изкуствен интелект

Кратко обяснение, генерирано от езиков модел по текста на CORDIS. Оригиналът е по-долу.

Резултати накратко

Regulation of mitochondrial expression

The main scientific focus of REMIX network was to further understand the molecular mechanism involved in regulation of mitochondrial gene expression that is coordinated by two different genomes. The mitochondrial genome (mtDNA) encodes for key subunits of the oxidative phosphorylation system all RNA components needed for their translation. All other factors needed for mitochondrial DNA replication, DNA repair, transcription and translation are encoded in the nucleus, made in the cytoplasm and then imported into mitochondria. Dysfunction of many different components involved in the regulation of mitochondrial gene expression underlies a great variety of human diseases and modulates organismal aging. To achieve this, REMIX network has recruited 15 highly motivated early stage researchers and over four years of REMIX ITN duration, train them to become the next generation leading scientists in the field. After the recruitment REMIX fellows began a scientific training in their own laboratories, and even more importantly through network-based activities. The extensive network-based training allowed REMIX fellows to form a highly coherent group that communicate on a daily basis sharing their protocols, ideas and successes. This communication is now further perpetuated by REMIX fellows themselves and resulted in a couple of very nice and collaborative publications. This strong and lasting connection between REMIX fellows is obviously an added value of the whole REMIX consortium. Scientific achievements and results obtained by REMIX fellows are no less impressive as they identified novel players and pathways involved in different steps of mitochondrial gene expression.

Текст от CORDIS, на английски · Данни: CORDIS, © Европейски съюз

Цел на проекта

Mitochondria are essential organelles found in every eukaryotic cell, required to convert food into usable energy. Themitochondrial oxidative phosphorylation (OXPHOS) system, which produces the majority of cellular energy in the form ofATP, is controlled by two distinct genomes: the nuclear and the mitochondrial genome (mtDNA). Mutations in mitochondrialgenes encoded by either genome could cause diseases affecting OXPHOS system, called mitochondrial diseases, whoseprevalence has been estimated to be ≈1:8500. Moreover, dysfunction of mitochondrial OXPHOS system has emerged as akey factor in a myriad of “common” diseases, including neurodegenerative and metabolic disorders like Parkinson’s andAlzheimer’s Disease, Type 2 Diabetes, and was linked to aging process. Despite all this, it is surprising that ourunderstanding of the mechanisms governing the mitochondrial gene expression and its associated pathologies remainsuperficial and therapeutic interventions unexplored. The basic machineries for mtDNA replication, mtDNA transcription andmitochondrial translation are known, but the regulation of these processes in response to metabolic demands is poorlyunderstood. The complex nature of mitochondrial gene expression that relies on two different genomes calls for amultidisciplinary approach where different teams of researchers join forces. Studies in this area are not only of basicscientific interest but may also provide new avenues towards treatment of mitochondrial dysfunction in a variety of humandiseases.The key aim of the REMIX Network is combine the skills of European research groups to provide strategic training of thenext generation of scientists through a programme that will progress in the elucidation of the molecular mechanisms andpathways that regulate mitochondrial gene expression.

Оригинален текст от CORDIS (на английски).

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Данни: CORDIS, © Европейски съюз