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КартаВръзкиТемиБългарияНощта (K-TRIO)Мария Склодовска-КюриЗа ученициЗа учителиМетодологияИзненадай ме
H2020Докторантска мрежа2017–2020

DNAREPAIRMAN · Regulated Assembly of Molecular Machines for DNA REPAIR: a Molecular Analysis training Network

„Хоризонт 2020“ — Действия „Мария Склодовска-Кюри“

Период
2017-01-01 → 2020-12-31
Финансиране от ЕС
3 079 270 €
Участници
13
Схема
MSCA-ITN-ETN

Линиите свързват координатора с партньорите.

Накратко на български

Молекулярните машини, които откриват и поправят грешки в ДНК, се анализират за разкриване на механизмите им на работа. Разбирането на тези процеси помага за разработването на нови антимикробни средства и персонализирани терапии срещу рак.

Този кратък обзор е генериран от изкуствен интелект

Кратко обяснение, генерирано от езиков модел по текста на CORDIS. Оригиналът е по-долу.

Резултати накратко

Regulated Assembly of Molecular Machines for DNA REPAIR: a Molecular Analysis training Network

The DNARepairMan training network (Regulated Assembly of Molecular Machines for DNA Repair: a Molecular Analysis Training Network) consists of 12 European participants coming from academia, industry and the creative sector. The network aims to train 12 young scientists in cutting edge biophysical research methodology to address central questions in biology with relevance for human health. This is motivated by the understanding that the future development of novel targeted therapies and antimicrobials will rely precisely on understanding the molecular and mechanistic details underlying disease. Our focus on the process of DNA repair arises from its essential role in maintaining genome stability. In this process multiple proteins collaborate as large molecular machines to detect and repair very rare errors that occur in DNA. These evolutionarily-conserved processes are of fundamental importance, and there is an increasing awareness that targeting of DNA repair pathways could also be useful in the development of personalized anti-cancer therapies and new antimicrobials. This Training Network uniquely brings together biologists, chemists, and physicists around a common research question: What are the mechanistic details that underlie the molecular organization of DNA repair? The objectives of DNARepairMan are - To unravel the mechanistic details of two DNA repair pathways and how they interact with DNA replication and transcription - To develop new reagents, assays, technology and software to analyze fundamental chemical and physical principles - collaborate with an Art Academy to explore new ways and means to visualize research projects and explain the importance of fundamental research to society.

Текст от CORDIS, на английски · Данни: CORDIS, © Европейски съюз

Цел на проекта

The European Training Network DNAREPAIRMAN aims to train a new generation of innovative young scientists in cutting edge biophysical research methodology to address central questions in biology concerning the mode of action of critical molecular machines with relevance for human health. The Network consists of a highly collaborative consortium consisting of 12 participants coming from academia, industry, and the creative sector. Participating laboratories in the Network are part of established research schools within renowned research organizations and Universities, with supervisors who are experts within their respective research field, publish regularly in high-impact journals and have received EURYI and ERC awards. This environment of excellence offers a multidisciplinary PhD program to 12 young researchers (ESRs), through training in the analysis of basic chemical and physical principles that underlie the correct timing and localization of events during DNA repair. In addition training will center around method development using methodology, equipment, software and experience provided first-hand by four small technology-driven companies. Individual research projects as well as personal training plans will be implemented for each ESR, incorporating a local training program, multiple rotations within partner laboratories, exposure to the non-academic sector and Network meetings. ESRs will follow scientific workshops, courses in transferable skills, career development and entrepreneurship, and will disseminate and communicate their projects to a diverse audience in close collaboration with the creative sector. DNAREPAIRMAN will result in a new generation of mature and innovative European scientists with a thorough understanding of fundamental quantitative principles underlying biology, with experience in technique development, and affinity for the academic as well as the non-academic research setting, providing a broad and promising career perspective.

Оригинален текст от CORDIS (на английски).

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Данни: CORDIS, © Европейски съюз