H2020Индивидуална стипендия2016–2018

ESOMAVOD · Enantioselective Synthesis of Madangamine Alkaloids via Organocatalytic Desymmetrization

„Хоризонт 2020“ — Действия „Мария Склодовска-Кюри“

Период: 2016-08-16 → 2018-08-15
Финансиране от ЕС: 195 455 €
Участници: 1
Схема: MSCA-IF-EF-ST

Линиите свързват координатора с партньорите.

Накратко на български

Методите за синтез на мадангамин алкалоиди, които се срещат в морски гъби, се разработват в лаборатория. Това позволява по-лесното им производство за изследване на противораковите им свойства и създаването на нови химични реакции.

Този кратък обзор е генериран от изкуствен интелект

Кратко обяснение, генерирано от езиков модел по текста на CORDIS. Оригиналът е по-долу.

Резултати накратко

Enantioselective Synthesis of Madangamine Alkaloids via Organocatalytic Desymmetrization

SUMMARY FOR PUBLICATION: During the course of this project, we have developed a new synthetic methodology towards the core of madangamine alkaloids, a family of six complex alkaloids isolated from a marine sponge, which have already shown cytotoxicity against different cancer cell lines. However, some of these compounds have not been studied yet due to the difficulty in isolation from the natural organisms. Therefore, it is highly desirable to develop a new methodology to prepare these compounds in a scalable fashion and in high yield. At the same time, the development of new reactions towards the preparation of fully substituted highly decorated amines is desirable because it can be applied as a new tool in the arsenal of reactions used in total synthesis.

Текст от CORDIS, на английски · Данни: CORDIS, © Европейски съюз

Цел на проекта

This project will develop a new, highly enantioselective, state-of-the-art synthetic route to madangamine alkaloids B, C and E based on a novel organocatalytic desymmetrization reaction as a key step, which will allow the rapid and efficient construction of the AC rings ready for subsequent advancement to the majority of the family members. Evaluation of the anti-cancer biological activity of the different madangamines and late stage intermediates will be carried out. This Fellowship project combines total synthesis, new asymmetric methodology development via organocatalysis and biological evaluation. This multidisciplinary Fellowship, based on high-quality and novel research at the University of Oxford, one of the top-research centres worldwide, has been designed to augment and complement Dr Vasu’s skills and knowledge to improve his career possibilities and, at the same time, Dr Vasu’s experience in new methodology development and catalysed transformations will be advantageous to the design of the organocatalyst in the key step of the synthesis. The Fellowship will also be useful to establish new collaboration opportunities for the Dixon group. Through the training and the research results arising, the Fellowship will be beneficial to the fellow, the host institution and European science.

Оригинален текст от CORDIS (на английски).

Участници

THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF OXFORD · OxfordКоординаторОбединеното кралство