H2020Индивидуална стипендия2017–2019

Smart Protocells · Generation of prototissues from functional and chemoselective protocells

„Хоризонт 2020“ — Действия „Мария Склодовска-Кюри“

Период: 2017-02-01 → 2019-01-31
Финансиране от ЕС: 183 455 €
Участници: 1
Схема: MSCA-IF

Линиите свързват координатора с партньорите.

Накратко на български

Изкуствени клетъчни мембрани се създават така, че да разпознават други подобни структури и да се обединяват в тъкани. Това помага за разбирането на процесите по самосглобяване и взаимодействие между клетките.

Този кратък обзор е генериран от изкуствен интелект

Кратко обяснение, генерирано от езиков модел по текста на CORDIS. Оригиналът е по-долу.

Резултати накратко

Generation of prototissues from functional and chemoselective protocells

Overall, the project achieved its objectives and milestones for the period. However, a few deviations from the original ideas were required. The main objective of the Smart Protocells project was the design and synthesis of novel protocell membranes capable of recognising each other, exchange materials, and self-assemble into prototissues. More specifically, the scientific objectives of the research project were the following: 1. The synthesis of novel block-copolymers containing dangling bioorthogonal functionalities. 2. The creation of functional and bioorthogonal protocells able to recognize partner protocells. 3. The development of techniques for the generation of macroscopic prototissues with high spatial and temporal control. As for the ER training objectives, they were as follows: 1. Provide a supportive environment for knowledge-exchange in the multidisciplinary and intersectoral field of protocell research. 2. Establish a tailored mentoring and training plan for career development in both academia and industry. A training plan for career development of the ER was established at the beginning of the fellowship. The ER improved his research skills by the completion of research activities, and attended workshops, conferences, and participated in outreach events to further hone his communication skills. A detailed description of these outreach activities is provided in the following section.

Текст от CORDIS, на английски · Данни: CORDIS, © Европейски съюз

Цел на проекта

Protocells are micro-compartments able to perform or mimic primitive biological functions of real cells. Because of this, they are proposed as stepping-stones towards the understanding of the origin of life on Earth. These “smart” microcapsules find potential applications in a variety of fields including medicine, pharmacology, energy conversion, and bioengineering. Progress in these fields will be considerably enhanced by gaining control over communication between protocells, as well as engineering collective functions of protocells.An important step towards the achievement of these goals can be made by employing bioorthogonal reactions. Bioorthogonal chemistry is a subclass of click chemistry that includes chemical reactions designed to occur in very complex media like the cell's cytosol. Bioorthogonal reactions are based on exogenous and atoxic reagents that react together quickly, chemoselectively and in quantitative yields. The introduction of bioorthogonal functionalities onto a protocell surface will open new possibilities in protocell engineering. In particular, the creation of bioorthogonally reactive protocells will represent the first step towards the creation of an unprecedented method for artificially controlling protocell communication and the assembly of prototissues with very high spatial and temporal control. The previous expertise of the applicant in the field of bioorthogonal chemistry and chemistry at the interface of materials will be applied to the multidisciplinary and emerging field of protocells in which the hosting group of Professor Stephen Mann FRS at the University of Bristol has been pioneering over the last few years. The key outcome of the combined research efforts of the applicant and the Mann group will lead to the synthesis of bioorthogonally reactive protocells and the investigation of their reactivity for the controlled exchange of biomaterials and the assembly of prototissues.

Оригинален текст от CORDIS (на английски).

Участници

UNIVERSITY OF BRISTOL · BRISTOLКоординаторОбединеното кралство