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КартаВръзкиТемиБългарияНощта (K-TRIO)Мария Склодовска-КюриЗа ученициЗа учителиМетодологияИзненадай ме
H2020Обмен на изследователи2017–2022

CARBO-IMmap · Immune activity Mapping of Carbon Nanomaterials

„Хоризонт 2020“ — Действия „Мария Склодовска-Кюри“

Период
2017-03-01 → 2022-02-28
Финансиране от ЕС
796 500 €
Участници
8
Схема
MSCA-RISE

Линиите свързват координатора с партньорите.

Накратко на български

Въглеродните наноматериали, като графен и въглеродни нанотръби, се анализират за това как взаимодействат с човешката имунна система. Това помага за разработването на нови методи за лечение, при които тези материали служат като носители на лекарства или за възстановяване на тъкани.

Този кратък обзор е генериран от изкуствен интелект

Кратко обяснение, генерирано от езиков модел по текста на CORDIS. Оригиналът е по-долу.

Резултати накратко

Immune activity Mapping of Carbon Nanomaterials

Long-term nanobiotechnology goal: The long-range goal of Carbo-IMmap is to develop a functional pipeline for the immune-characterization of carbon nanomaterials, for the qualitative and quantitative assessment in vitro and ex vivo of the human immune compatibility and immune activity of newly developed carbon materials. Long-term nanomedical goal: The functional pipeline will be used for the accurate immune mapping of graphene oxide, aminated graphene, exfoliated graphene, graphene nanoribbons, functionalized carbon nanotubes and carbon nanotube fibers. The accurate immuno-characterization of the tested materials on the basis of intrinsic physical-chemical features and immunological properties will open breakthrough perspectives for the development of new therapeutic approaches applying nanomaterials as immunomodulators, immunotherapetutic agents, molecular vectors and scaffolds for tissue regeneration/engineering. Key implementation aspects: The innovative pipeline will ground on computational modelling systems to predict the materials behaviours in the biological fluids and their interaction with biomolecules. The modelling strategy will be coupled with a wide array of high throughput assays based on immune-phenotypic and immune-genomics analysis providing the simultaneous detection of multiple effects on the five major immune cell populations and ex vivo on the highly complex immune blood cell pool. The combination of the most innovative technologies (12-colour Flow cytometry, ImageStream, CyTOF, single cell gene expression), allowing multiplex analysis of many cell types, will provide a forefront approach to investigate the immune impact. Scientific impact: The successful development and optimization of the functional pipeline for the characterization of the immune activity of newly synthesized, stable carbon nanomaterials will greatly advance the engineering process of carbon nanomaterials. The implication of this project extend beyond the specific nanoscience program. The unprecedented testing of 5 different types of materials to assess jointly the effect of different parameters (such as size and chemical functionalization) on all major type of immune blood cells, is a step ahead in basic research attempting to predict nanomaterial immune activity and to take advantage of their potential immunomodulation feature.

Текст от CORDIS, на английски · Данни: CORDIS, © Европейски съюз

Цел на проекта

The CARBO-IMmap project involves key players in Europe, US, Qatar and China with the aim to advance the field of carbon nanomaterial development and their exploitation biomedical applications. The long-range goal of Carbo-IMmap is to develop a functional pipeline for the immune-characterization of carbon nanomaterials, for the qualitative and quantitative assessment in vitro and ex vivo of the human immune compatibility and immune activity of newly developed carbon materials.The project aims to: 1) design and synthetize a panel of 5 types of highly stable and water-soluble nanomaterials, characterized by finely tuned properties by controlling their size and composition, and to obtain these nanomaterials in large amounts with nearly identical size and shape and degree of functionalization; 2) achieve a quantitative understanding of the immune activity (stimulation/ anergy/ suppression) of the selected materials upon the 5 subpopulations of the immune blood cells; 3) correlate the physicochemical properties (size and chemical functionalization) of the nanomaterials with their immune properties; 4) establish a consolidated network between leading EU and extra-EU institutes to provide a stimulating international environment for talented young researchers; 5) advance the level of R&D in participant countries and foster technology transfer and dissemination; 6) raise the awareness of the general public on the prospects of carbon nanomaterials in future biomedical applications. Scientists will be formed by ""training by research"" stays at host labs, leading to an interdisciplinary and international formation.Funding of this program will enable long-term, transformative research collaborations that will contribute to the integration and collaboration of research groups of 4 European Countries (Germany, Italy, France and Spain) and 3 key non-EU Countries: USA, China and Qatar.""

Оригинален текст от CORDIS (на английски).

Участници

Връзки

Данни: CORDIS, © Европейски съюз