H2020Докторантска мрежа2017–2021

INTRICARE · International Network for Training on Risks of vascular Intimal Calcification And roads to Regression of cardiovascular diseasE

„Хоризонт 2020“ — Действия „Мария Склодовска-Кюри“

Период: 2017-03-01 → 2021-08-31
Финансиране от ЕС: 3 832 965 €
Участници: 3
Схема: MSCA-ITN

Линиите свързват координатора с партньорите.

Накратко на български

Микрокалцификациите в стените на кръвоносните съдове, като тези при диабет и бъбречни заболявания, се изследват като причина за руптура на плаките. Това помага за по-доброто разбиране на механизмите на атеросклерозата и разработването на методи за ранна диагностика и лечение.

Този кратък обзор е генериран от изкуствен интелект

Кратко обяснение, генерирано от езиков модел по текста на CORDIS. Оригиналът е по-долу.

Резултати накратко

International Network for Training on Risks of vascular Intimal Calcification And roads to Regression of cardiovascular diseasE

Cardiovascular disease remains one of the major challenges of contemporary society, being responsible for a staggering 47% of deaths in Europe. Most cardiovascular diseases arise from thrombotic rupture of an atherosclerotic plaque, the pathologic thickening of (coronary and carotid) artery segment and subsequent distal ischemia in heart or brain (infarct, cardiac arrest and stroke). In fact, 20% of European deaths are directly attributable to thrombotic rupture of a vulnerable plaque; a clear indication that current treatments and preventive measures are insufficient. Recent reports demonstrate that intimal vascular calcification, especially punctuated and spotty calcifications (microcalcifications) in the plaque are life-threatening. Microcalcifications are particularly prominent in the vulnerable atherosclerotic plaque that is at high risk of rupture. Interestingly, a high level of vascular calcification frequently occurs in two major cardiovascular comorbidities, type 2 diabetes and chronic kidney diseases, identifying vascular calcification as a shared culprit in profoundly elevated risk of cardiovascular diseases and as an excellent new target for intervention. The objective of INTRICARE is to train a new generation of scientist that will be excellently skilled to expedite our understanding of vulnerable plaque formation, with a particular focus on microcalcification, and to develop innovative solutions for the early prevention, treatment and diagnosis of atherosclerosis.

Текст от CORDIS, на английски · Данни: CORDIS, © Европейски съюз

Цел на проекта

Cardiovascular disease remains one of the major challenges of contemporary society, being responsible for a staggering 47% of deaths in Europe. Vascular calcification in particular requires immediate attention as it is strongly associated with increased cardiovascular mortality and morbidity, and is recognised as an important independent risk factor for cardiovascular death. Recent reports demonstrate that especially punctuated and spotty calcifications (microcalcifications) in the plaque are life-threatening. Microcalcifications are particularly prominent in the vulnerable atherosclerotic plaque that is at high risk of rupture, a cardinal event that can cause thrombosis, infarct, cardiac arrest, stroke and death. In fact, 20% of European deaths are directly attributable to thrombotic rupture of a vulnerable plaque; a clear indication that current treatments and preventive measures are insufficient. Recent findings suggest a link between vascular smooth muscle cell phenotype mediated calcification and inflammation, which could underlie the plaque destabilising effects of microcalcification. However, a comprehensive view on what causes microcalcification and its impact on plaque stability remains elusive and there is an urgent need to translate experimental findings into adequate diagnostic, preventive and therapeutic solutions. INTRICARE is shaped to address the urgent unmet medical needs concerning calcification-induced vulnerable plaques and is guided by the academic and industrial demand for a new generation of entrepreneurial scientists that have the skills, expertise and knowhow to expedite our understanding of vascular calcification and translation thereof into concrete, effective clinical solutions. The INTRICARE ESRs harbour ongoing vitamin K-supplementation trials that will be pivotal in the identification of selective biomarkers for microcalcification and subsequent development of strategies for prevention or amelioration of vulnerable plaque formation.

Оригинален текст от CORDIS (на английски).

Участници

UNIVERSITEIT MAASTRICHT · MaastrichtКоординаторНидерландия
KAROLINSKA INSTITUTET · STOCKHOLMШвеция
UNIVERSITAETSKLINIKUM AACHEN · AachenГермания