H2020Индивидуална стипендия2017–2019

MorphGrad · Morphogen-like properties of small RNA gradients: A new paradigm for the role of small RNAs in developmental biology

„Хоризонт 2020“ — Действия „Мария Склодовска-Кюри“

Период: 2017-03-01 → 2019-02-28
Финансиране от ЕС: 159 461 €
Участници: 1
Схема: MSCA-IF

Линиите свързват координатора с партньорите.

Накратко на български

Малките РНК се изследват като пратеници, които се движат между клетките, за да им подскажат къде се намират в растящия организъм. Това помага да се разбере как се контролира комуникацията между клетките по време на развитието на многоклетъчните същества.

Този кратък обзор е генериран от изкуствен интелект

Кратко обяснение, генерирано от езиков модел по текста на CORDIS. Оригиналът е по-долу.

Резултати накратко

Morphogen-like properties of small RNA gradients: A new paradigm for the role of small RNAs in developmental biology

This fellowship investigated the mechanisms by which small RNAs function as novel intercellular messengers that provide important developmental signals. Coordinated development of multicellular organisms depends on the ability of cells to assess their relative positions within the growing organism. This is achieved through intercellular communication, commonly based on the production and perception of mobile signaling molecules. In addition to the well-established peptide ligands, transcription factors, and hormones, small RNAs have emerged as a new class of mobile instructive signals in development. Small RNAs possess intrinsic properties that make them particularly well suited to drive developmental change. These include a high degree of specificity, a direct and rapid mode of action, and the ability to confer sensitivity and robustness onto gene regulatory networks. One additional obvious advantage of employing mobile small RNAs in development is that they represent a distinct class of signaling molecules whose movement can, in principle, be regulated independently from that of other mobile signals. However, despite its central importance, an understanding of how the cell-to-cell movement of small RNAs is governed has been lacking. This fellowship investigated the mechanisms by which small RNAs move from cell to cell and function as novel intercellular messengers that provide important developmental signals.

Текст от CORDIS, на английски · Данни: CORDIS, © Европейски съюз

Цел на проекта

This fellowship will investigate the mechanisms by which small RNAs function as novel intercellular messengers that provide important developmental signals. By manipulating various small RNA gradient and target parameters, the proposed research seeks to understand how small RNA gradients are interpreted into sharp gene expression domains. The findings from the proposed experiments will provide important insight into the patterning properties of small RNA gradients, and their role in conferring robustness to developmental programs in both plants and animals. The approach taken is a multidisciplinary one that integrates mathematical modelling with qualitative experimental data, generated from a novel reporter system and state-of-the-art confocal imaging and image analysis. The outcome will be a new paradigm for how miRNAs function in development, which will provide important insight into the patterning properties of small RNA gradients.

Оригинален текст от CORDIS (на английски).

Участници

EBERHARD KARLS UNIVERSITAET TUEBINGEN · TuebingenКоординаторГермания