H2020Индивидуална стипендия2017–2019

ChiPyrNMR · Better tools for combating insect borne diseases by understanding influences on the fate of common pesticides in paint formulations

„Хоризонт 2020“ — Действия „Мария Склодовска-Кюри“

Период: 2017-09-01 → 2019-08-31
Финансиране от ЕС: 165 599 €
Участници: 1
Схема: MSCA-IF-EF-SE

Линиите свързват координатора с партньорите.

Накратко на български

Стабилността на пиретроидите (безопасни инсектициди) в боите се анализира чрез ЯМР спектроскопия, за да се разбере как се разграждат тези вещества. Това помага за по-ефективен контрол на болести, пренасяни от комари, като малария, зика и денге.

Този кратък обзор е генериран от изкуствен интелект

Кратко обяснение, генерирано от езиков модел по текста на CORDIS. Оригиналът е по-долу.

Резултати накратко

Better tools for combating insect borne diseases by understanding influences on the fate of common pesticides in paint formulations

Malaria is a life-threatening disease caused by parasites transmitted to people through the bites of infected mosquitoes. Approximately half of the world’s population is at risk of malaria: in 2017, 87 countries and territories suffered from ongoing malaria transmission.i The World Health Organisation (WHO) only declared Europe malaria free as recently as 2016,ii nevertheless it is important to prevent its return. Zika virus, dengue fever and yellow fever are other examples of diseases transmitted by mosquitoes belonging to the genus Aedes; for all these diseases, a vaccine is not yet available or is under clinical trials; therefore, WHO affirms that prevention control is the main way to reduce their spreading, and the use of insecticides constitutes one of the key measures.iii Insecticidal paints were shown to have comparable performances with respect to other forms of effective vector control, with advantages from several points of view, such as economic, practical and environmental.iv The active ingredients of all WHO-recommended vector controls come from only four classes of insecticides: pyrethroids, organochlorines, organophosphates and carbamates.v We selected pyrethroids as our test insecticide because these compounds are the safest for public health use from both a human and an environmental point of view.vi,vii The topic of the ChiPyrNMR project has been the analysis of chiral pyrethroids aiming at understanding, controlling and improving their stability in complex matrices like paint. NMR spectroscopy was selected as main analytical technique because it allows to investigate in-situ interaction and degradation phenomena at a molecular levelviii and it is already largely employed in paint characterization.ix

Текст от CORDIS, на английски · Данни: CORDIS, © Европейски съюз

Цел на проекта

Malaria, Zika virus, dengue fever and yellow fever are mosquito transmitted diseases for which a vaccines either do not exists or are not widely available. Prevention control is the main way to reduce their spread, and the use of insecticides constitutes one of the key measures recommended by World Health Organisation. New innovative methods of bringing the insects into contact with the insecticides include the development of insecticidal paint with the advantage of safer application, targeted dosing and significantly reduced risk of collateral damage to humans and the environment. This project will address some of the challenges in developing these solutions. Pyrethroids are one of the best insecticides for public health use but suffer from hydrolysis and photo-degradation. Little is known about how their application in paint formulations affects this behavior. At a chemical level the biological activity of the individual enantiomers is determined by the configuration of their chiral centers, so accurately quantifying the enantiomeric composition is critical to tracking potential degradation. The aim of this project is to generate robust methods for a better understanding of the fate of insecticides in complex matrices like paint. Once the nature of the degradation products and the related mechanisms is clear, the formulation can be adjusted to minimize the occurrence of degradation or enhance active ingredient protection. The kinetic analysis of the degradation processes and the interaction/stability studies are best performed in-situ avoiding potentially invasive extraction sample preparation steps, so the powerful tools of advanced NMR spectroscopy will be exploited to characterize these phenomena. The knowledge gained will be used to validate/explain multidisciplinary laboratory biological trial results on mosquitoes and be able to be exploited more widely to other systems and support the research into other compounds for potential deployment in this way.

Оригинален текст от CORDIS (на английски).

Участници

NOURYON CHEMICALS B.V. · ARNHEMКоординаторНидерландия