H2020Индивидуална стипендия2017–2019

NeuroModSense · Peptidergic Neuromodulation of Sensory Representation in the Brain

„Хоризонт 2020“ — Действия „Мария Склодовска-Кюри“

Период: 2017-03-01 → 2019-02-28
Финансиране от ЕС: 208 400 €
Участници: 1
Схема: MSCA-IF-EF-ST

Линиите свързват координатора с партньорите.

Накратко на български

Невронните клетки, секретиращи пептидите GnRH и NPY, се изследват за това как влияят върху обработката на миризми при хранене и размножаване. Това помага да се разбере как мозъкът адаптира поведението ни спрямо вътрешни състояния като глад или стрес.

Този кратък обзор е генериран от изкуствен интелект

Кратко обяснение, генерирано от езиков модел по текста на CORDIS. Оригиналът е по-долу.

Резултати накратко

Peptidergic Neuromodulation of Sensory Representation in the Brain

We interact with and respond to our environment by processing sensory inputs such as visual and auditory cues and touch, taste and smell. Neuromodulators constantly modulate these sensory representations in the brain to adapt our behaviour to changes in the internal (e.g. sleep, wakefulness, stress, fed or hungry conditions) and external (e.g. danger) environment. The main objective of this proposal is to investigate the role and mechanism of neuromodulatory neurons, GnRH/NPY secreting neurons, in chemosensory processing and behaviour. Gonadotropin releasing hormone (GnRH) and neuropeptide Y (NPY) are neuropeptides that are conserved across vertebrates and modulate feeding and reproductive behaviours, respectively. They are produced by discrete population of neurons in the brain and are dispersed widely throughout the brain. Past studies have shown that GnRH promotes the release gonadotropin and is known to modulate reproductive behaviours in vertebrates. NPY is involved in an increased food intake in vertebrates and has been shown to modulate olfactory responses to food odour in hungry animals. However, it is not known how GnRH/NPY neurons influence the processing of chemosensory information in the olfactory bulb (OB) and ultimately odour driven behaviour. We found that GnRH neurons respond to the chemosensory information. Their responses are sexually dimorphic and are modulated by satiety. Their activity is necessary for odour driven feeding and reproductive behaviours. Our result implies a central role of these neurons in mediating odour driven feeding and reproduction. Moreover, we continue to work towards understanding the role of NPY neurons in sensory processing and behaviour.

Текст от CORDIS, на английски · Данни: CORDIS, © Европейски съюз

Цел на проекта

Animals interact with and respond to their environment by processing sensory inputs such as visual and auditory cues, touch, taste and smell. How an animal responds to sensory inputs however depends on its internal state (e.g. sleep, wakefulness, stress, fed or starved conditions), such that the same sensory input can produce different behaviours. Neuromodulators play an important role in mediating the internal state of the animal. Neuropeptide Y (NPY) and Gonadotropin-releasing hormone (GnRH) are neuropeptides that are conserved across vertebrates and modulate feeding and reproductive behaviours, antagonistically. They are produced by discrete neuronal populations, and are dispersed widely throughout the brain. Studies suggest that both GnRH/NPY modulate the basal olfactory response by altering the synaptic properties of olfactory receptor neurons. However, it is not known how GnRH/NPY influence the processing of chemosensory information in the olfactory bulb (OB) and ultimately odour driven behaviour. Here, I will use an optically transparent and genetically amenable vertebrate model, zebrafish to study brain function and behaviour. First, I will use genetic methods to specifically label, and visualise the activity of the GnRH/NPY neurons in response to natural odours ex vivo. Next, I will manipulate the activity of these neurons using optogenetics and by expressing neurotoxin/cell ablation genes, and study the effect on olfactory processing in the OB. Finally, after manipulating the activity of GnRH/NPY neurons, I will analyse the effect on odour driven behaviour. This will reveal the role of these neuromodulators in olfactory processing and hence on odour driven behaviour in vertebrates. This project unites my expertise in molecular genetics with that of my host in frontier neuroscience to address a fundamental question of sensory processing, relevant for understanding disorders in which behaviour is decoupled from internal state (e.g. obesity/anorexia).

Оригинален текст от CORDIS (на английски).

Участници

NORGES TEKNISK-NATURVITENSKAPELIGE UNIVERSITET NTNU · TrondheimКоординаторНорвегия