H2020Индивидуална стипендия2017–2019

LTPAM · Low Temperature Plasma for Applications in Medicine

„Хоризонт 2020“ — Действия „Мария Склодовска-Кюри“

Период: 2017-05-01 → 2019-04-30
Финансиране от ЕС: 172 800 €
Участници: 1
Схема: MSCA-IF-EF-ST

Линиите свързват координатора с партньорите.

Накратко на български

Нискотемпературната плазма и нейните реактивни частици се изследват за приложение при ракови заболявания. Разбирането на взаимодействието им с тъканите помага за преодоляване на скептицизма и прилагането на този метод в медицината.

Този кратък обзор е генериран от изкуствен интелект

Кратко обяснение, генерирано от езиков модел по текста на CORDIS. Оригиналът е по-долу.

Резултати накратко

Low Temperature Plasma for Applications in Medicine

Atmospheric pressure low temperature plasmas (LTPs) are attracting a lot of attention due to their vast biomedical potential. Specifically, the emerging field of LTP employment in anti-cancer research and clinical studies is of high importance. Plasmas generate a variety of molecular, ionic and radical reactive oxygen and nitrogen species (RONS) upon interaction with ambient gas and aqueous environment of biological substrates. Understanding how LTPs interact with their surroundings and thus being able to tailor the species cocktail and the respective effect is crucial for successful medicinal applications. Despite plasma therapy being a very promising anti-cancer modality, it meets a lot of scepticism and hindrance from researchers, medical bodies, and the general public. Reasons for this lay in incomplete understanding of even the fundamental LTP properties, such as the reactivity of its various compartments, its interaction with components of biological media and tissues, etc. By elucidating and explaining the effects of LTP in various environments and on different targets, we succeeded in bringing LTP closer to wider clinical applications, contributing to a healthier society.

Текст от CORDIS, на английски · Данни: CORDIS, © Европейски съюз

Цел на проекта

Atmospheric pressure low temperature plasma (LTP) is a burgeoning field due to its vast potential in biomedical applications. Reacting with ambient air, these plasmas generate a variety of molecular, ionic and radical species, responsible for the anti-bacterial, anti-viral and anti-cancer properties of LTP. It is especially important when more traditional therapies fail, such as antibiotic-resistant bacteria. Recently, a large number of studies of the biological effects of LTP emerged, as well as diagnostics of the gas phase LTP, and various models. However, the chemical and physical processes in biologically relevant media still lack detailed understanding. Water is an essential part of the bio-milieu, and both initial and secondary LTP-induced chemistries in liquids require deeper studies. This project will aim at several goals, which will aid the progression of LTP towards wide and diverse clinical use. 1) It will utilise the RF COST plasma jet (created to standardise the LTP research in Europe and the world). The sources of the reactive species induced by the jet will be studied by employing isotopically labelled molecules. 2) The plasma-induced chemistry will be studied in conditions mimicking those in vivo: (i) generation of secondary species from Cl-, one of the most abundant chemicals in bio-media, and assessment of their cytotoxicity; and (ii) quantitative identification of short-lived reactive species (radicals) created by LTP in gels, structures resembling tissue (this is especially important in the case of direct plasma exposure where radical chemistry greatly influences processes in liquids). 3) The enhancement of LTP effects will be studied via generation of ONOO- from its precursors in plasmas with aerosols. The work will be focussed on liquids’ analysis by electron paramagnetic resonance and nuclear magnetic resonance spectroscopy, mass spectrometry, ion chromatography, etc.

Оригинален текст от CORDIS (на английски).

Участници

UNIVERSITEIT ANTWERPEN · AntwerpenКоординаторБелгия