H2020Индивидуална стипендия2017–2019

EPOFFSPRING · Epigenetic mechanisms underlying the influence of paternal drug experience on offspring behavior

„Хоризонт 2020“ — Действия „Мария Склодовска-Кюри“

Период: 2017-03-01 → 2019-02-28
Финансиране от ЕС: 195 455 €
Участници: 1
Схема: MSCA-IF

Линиите свързват координатора с партньорите.

Накратко на български

Епигенетичните механизми изследват как опитът на бащата с наркотици влияе върху поведението на потомството чрез промени в гените за допамин. Това помага за разбирането на начина, по който околната среда се предава между поколенията и влияе върху мозъка.

Този кратък обзор е генериран от изкуствен интелект

Кратко обяснение, генерирано от езиков модел по текста на CORDIS. Оригиналът е по-долу.

Резултати накратко

Epigenetic mechanisms underlying the influence of paternal drug experience on offspring behavior

The effect of paternal environmental impacts on psychology and related diseases of babies has been concern of the public. Those impacts include pollution, stress, nicotine intaking, alcohol consumption and so on. Such an idea of transmitting paternal environmental impact across generations has been indicated and described in studies across species, but the mechanism is still unclear. The overall aim of the project was to test whether H3K27me3, a type of epigenetic modification on histone 3 influencing gene expression, is involved in transmitting environmental impact across generation to influence the behavior of offspring. With a behavioral neuroscience background, the experienced research (ER) applied his expertise in high throughput behavioral assay and combined techniques he learned from the host lab, including epigenetic profiling, next generation sequencing, targeted epigenome editing and computational analysis to address specifically whether paternal drug experience influenced offspring behavior via modifying H3K27me3 on dopamine-related genes that are involved in various behaviors. Besides advancing our understanding of the importance and mechanism of paternal inheritance and the role of epigenetics in general, this project would also further extend zebrafish as a model in studying cross-generational transmission of environmental experience by combining multidisciplinary techniques. The trainings ER received would be beneficial and essential for his future goal to study epigenetic mechanisms underlying physiology and pathology of brain.

Текст от CORDIS, на английски · Данни: CORDIS, © Европейски съюз

Цел на проекта

The idea of transmitting paternal environmental impact across generations has been indicated and described in studies across species, but the mechanism is still unclear. The overall aim of the project is to test whether H3K27me3, a type of epigenetic modification on histone 3 [1], is involved in transmitting environmental impact across generation to influence the behavior of offspring. With a behavioral neuroscience background, the experienced research (ER) will apply his expertise in high throughput behavioral assay and combine techniques he will learn from the host lab, including epigenetic profiling, NGS, targeted epigenome editing and computational analysis to address specifically whether paternal drug experience influence offspring behavior via modifying H3K27me3 on dopamine-related genes that are involved in various behaviors [2]. Besides advancing our understanding of the importance and mechanism of paternal inheritance and the role of epigenetics in general, this project will also further extend zebrafish as a model in studying cross-generational transmission of environmental experience by combining multidisciplinary techniques. The trainings ER will be beneficial and essential for his future goal to study epigenetic mechanisms underlying physiology and pathology of brain.

Оригинален текст от CORDIS (на английски).

Участници

THE UNIVERSITY OF BIRMINGHAM · BirminghamКоординаторОбединеното кралство