H2020Индивидуална стипендия2017–2019

VALENCE-REPLAY · Disentangling amygdala contributions to replay-mediated, hippocampal-dependent memory consolidation

„Хоризонт 2020“ — Действия „Мария Склодовска-Кюри“

Период: 2017-10-15 → 2019-10-14
Финансиране от ЕС: 171 461 €
Участници: 1
Схема: MSCA-IF-EF-ST

Линиите свързват координатора с партньорите.

Накратко на български

Взаимодействието между хипокампуса и амигдалата по време на сън се проучва чрез наблюдение на животни след излагане на положителни стимули. Това помага да се разбере как сънят влияе върху обработката на емоционалните спомени и психическото здраве.

Този кратък обзор е генериран от изкуствен интелект

Кратко обяснение, генерирано от езиков модел по текста на CORDIS. Оригиналът е по-долу.

Резултати накратко

Disentangling amygdala contributions to replay-mediated, hippocampal-dependent memory consolidation

Information based economies rely on a highly skilled workforce, where individuals work increasingly with their minds rather than their hands. A mentally healthy workforce is central if Europe is to achieve its economic and development goals. One ingredient of good mental health is adequate sleep, which increasingly takes second place to busy, demanding lifestyles. Sleep can affect mental function in two interrelated ways: through regulation of emotional reactivity and through its role in offline memory consolidation. While these two factors have been studied mostly in isolation the underlying brain dynamics and interactions between relevant brain areas remain poorly studied. This project investigated how the emotional content of wake experience influences memory processing in periods of sleep. Two brain structures, the hippocampus and amygdala, are indispensable brain areas for memory formation and emotional processing, respectively. Their interaction during sleep remains is under-studied. Studies that begin to examine this issue have focused on rodent behavioral tasks with negative valence such as fear conditioning while much less has been done in the context of positive valence. Here the electrophysiological underpinnings of interaction between the ventral hippocampus and the basolateral amygdala were investigated using a novel behavioral paradigm, that allows to study offline periods after animals are exposed to a positive valence stimulus. Results suggest that the two brain structures extend their interactions into periods of rest supporting a mechanistic role for ventral hippocampus and amygdala in memory consolidation processes. While results are of basic nature, they highlight the significance of sleep in emotional memory processing. Further investigations will be needed to examine how these results might relate to sleep and mental well-being in humans.

Текст от CORDIS, на английски · Данни: CORDIS, © Европейски съюз

Цел на проекта

In today’s societies, adequate rest takes second place to busy professional and personal schedules. It is known that lack of rest and sleep affects mental health, emotional regulation and daytime function. Such symptoms translate to increased healthcare costs and losses in workplace productivity. How emotional regulation processes interact with sleep and associated memory consolidation functions is not well understood. In addition to increasing basic understanding of brain function, addressing this knowledge gap can help shape therapeutic approaches for mental wellbeing and contribute to EU’s H2020 goals of smart, sustainable and growth. VALENCE-REPLAY will provide a building block towards addressing this knowledge gap through experiments in behaving rodents. The questions to be addressed in this fellowship are: Are memory consolidation processes during sleep preferentially shaped according to the valence of prior experience? If this is so, how is this accomplished at a mechanistic level? The work will use modern electrophysiology and optogenetic techniques to probe functional interactions of brain areas that mediate emotion (amygdala) and memory (hippocampus) and the role of these interactions in memory replay and consolidation during sleep. The project will also lead to fabrication of a new tool, parylene-based multisite neuronal recording probes that will permit tracking single neuron activity from the ventral hippocampus for adequate lengths of time to address the outlined research goals.The fellowship will shed light on how emotions shape memory processes during sleep, but will also afford a committed and experienced researcher the opportunity to acquire advanced training at leading European neuroscience institutes while forming a strong scientific network with leaders in the field. Through VALENCE-REPLAY, Dr Perentos will develop into an independent researcher, able to lead his own research group and achieve high impact research in systems neuroscience.

Оригинален текст от CORDIS (на английски).

Участници

LUDWIG-MAXIMILIANS-UNIVERSITAET MUENCHEN · PlaneggКоординаторГермания